Disposable and/or replenishable transdermal drug applicators and methods of manufacturing same
First Claim
1. A method of manufacturing a transdermal drug applicator which is electrically activated, comprising the steps of:
- a. applying conductive coated areas to one surface of a substrate for use in said drug applicator;
b. folding said conductive coated areas so as to provide electrical conductors leading to the other surface of the substrate;
c. applying at least one occlusive adhesive dam to a surface of another substrate;
d. adding at least one drug reservoir to said surface of said another substrate in areas not occupied by said occlusive adhesive dam;
e. applying at least one drug reservoir to a portion of at least one of said electrical conductors; and
f. joining together said substrate and said another substrate to form a construction in which said drug reservoirs and said occlusive adhesive dam are contained between said substrates.
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Accused Products
Abstract
An electrically/battery powered transdermal drug applicator comprising a flexible non-conductive substrate with a plurality of conductive coated areas, the conductive coated areas forming drug reservoir electrodes, and a plurality of drug reservoirs separated by occlusive adhesive dams and in electrical contact with said drug reservoir electrodes. The battery is connected to the electrodes of the drug reservoirs and said applicator including electrical current conditioning means, with a conformal cover adhesively secured to said transdermal drug applicator and with a release liner covering and protecting said plurality of drug reservoirs until use.
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Citations
25 Claims
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1. A method of manufacturing a transdermal drug applicator which is electrically activated, comprising the steps of:
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a. applying conductive coated areas to one surface of a substrate for use in said drug applicator; b. folding said conductive coated areas so as to provide electrical conductors leading to the other surface of the substrate; c. applying at least one occlusive adhesive dam to a surface of another substrate; d. adding at least one drug reservoir to said surface of said another substrate in areas not occupied by said occlusive adhesive dam; e. applying at least one drug reservoir to a portion of at least one of said electrical conductors; and f. joining together said substrate and said another substrate to form a construction in which said drug reservoirs and said occlusive adhesive dam are contained between said substrates. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11)
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2. The method of manufacturing an electrically activated transdermal drug applicator, comprising the steps of:
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a. applying a conductive material to one surface of a first substrate; b. folding the conductive material away from itself to create a first conductive surface and a second, opposed conductive surface; c. applying at least one occlusive adhesive dam to a surface of a second substrate; d. adding at least one drug reservoir to the surface of the second substrate in areas not occupied by the occlusive adhesive dam; e. applying at least one drug reservoir to a portion of at least one of the conductive surfaces of the first substrate; and f. joining together the first and second substrates whereby the drug reservoirs and the occlusive adhesive dam are contained between the substrates. - View Dependent Claims (12, 13, 14, 15)
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16. A method for making a replaceable disposable drug reservoir for an electrically powered transdermal drug applicator, comprising the steps of:
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a. providing a substrate; b. depositing on said substrate occlusive adhesive dam material to define a plurality of drug reservoir compartments; c. laminating an open cell foam material to said substrate over said occlusive adhesive dam material; and d. filling said plurality of drug reservoir compartments with drug mixtures.
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17. A transdermal drug applicator which is electrically powered, comprising:
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a flexible, non-conductive substrate having a plurality of conductive coated areas, said conductive coated areas forming drug reservoir electrodes, battery electrodes and interconnections; a plurality of drug reservoirs separated by occlusive adhesive dams and in electrical contact with said drug reservoir electrodes and; a battery connected in series with the electrodes of the drug reservoir.
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18. A method for making a replaceable disposable drug reservoir for an electrically powered transdermal drug applicator, comprising the steps of:
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a. providing a substrate; b. depositing occlusive adhesive dam material on the substrate to define a plurality of drug reservoir compartments; c. laminating a foam material to the substrate over the occlusive adhesive dam material; and d. filling at least one of the plurality of drug reservoir compartments with a drug mixture. - View Dependent Claims (19, 20)
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21. An electrically powered transdermal drug applicator comprising:
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a flexible non-conductive substrate having a plurality of conductive areas forming drug reservoir electrodes, battery electrodes and interconnections; a plurality of drug reservoirs separated by occlusive adhesive dams, the drug reservoirs in electrical contact with the drug reservoir electrodes; and a battery connected in series with the drug reservoirs. - View Dependent Claims (22, 23, 24, 25)
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Specification