Detachable endovascular occlusion device activated by alternating electric current

• US 5,976,131 A
• Filed: 06/18/1996
• Issued: 11/02/1999
• Est. Priority Date: 03/13/1990
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Guglielmi, Guido, Ji, Cheng
• Primary Examiner(s): Cohen, Lee
• Application Number:
  US08/666,804
• Time in Patent Office: 1,232 Days
• Field of Search: 606/32, 606/41, 606/40, 606/49
• US Class Current: 606/49
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2017/00026 Conductivity or impedance, e.g. of tissue
• CPC Class Codes: A61B 2017/12063 electrolytically detachable
• CPC Class Codes: A61B 2017/12068 detachable by heat
• CPC Class Codes: A61B 2018/00875 Resistance or impedance
• CPC Class Codes: A61B 2018/1435 Spiral

Abstract

An apparatus is provided for electrocoagulating blood and tissue at an occlusion site by means of application of an alternating signal or current through a detachable partially insulated coil on the end of a microcatheter. A Guglielmi Detachable Coil (GDC) is preferably used in the combination with damped radio frequency energy to cause local heating at the location of the coil but without local ohmicly heated tissue damage or hot spots. Damping of the radio frequency energy facilitates the avoidance of hot spots. Once carbonization of blood at the detachment zone of the GDC coil occurs, the impedance of the entire system increases. The impedance increase is detected to automatically turn off the alternating current and then to apply a direct current to electrolytically detach the GDC coil from the microcatheter.

Claims

1. An apparatus for selectively providing endovascular occlusion in a patient comprising:

a delivery wire guidable to or near an endovascular occlusion site;

a detachable conductive coil temporarily and selectively coupled to said delivery wire; and

an alternating current generator selectively coupled to said detachable coil for delivering damped RF power signals to said occlusion site,

whereby a controllable occlusive apparatus efficacious and usable in small vessels is provided.

2. The apparatus of claim 1 further comprising:

a direct current generator selectively coupled to said detachable coil; and

a switch for selectively coupling said alternating current generator and direct current generator to said detachable coil.

3. The apparatus of claim 2 wherein said coil has a distal tip and is partially insulated at said distal tip to reduce nonuniform ohmic heating arising from direct contact of said distal tip with tissue at said occlusion site.

4. The apparatus of claim 2 wherein said direct current generator is variably controllable.

5. The apparatus of claim 2 wherein said alternating and direct current generators are variably controllable.

6. The apparatus of claim 1 wherein said coil is at least partially insulated.

7. The apparatus of claim 1 wherein said coil is selectively insulated to reduce nonuniform ohmic heating arising from direct contact between said coil and tissue at said occlusion site.

8. The apparatus of claim 1 wherein said alternating current generator is variably controllable.

9. The apparatus of claim 6 wherein said controllable alternating current generator is frequency controllable.

10. The apparatus of claim 1 further comprising a sensing circuit for determining when a predetermined state of electrocoagulation is achieved at or near said detachable coil.

11. The apparatus of claim 10 wherein said sensing circuit senses impedance of said detachable coil within said patient.

12. The apparatus of claim 10 further comprising a control circuit for selectively initiating detachment of said coil when said sensing circuit determines said predetermined state of electrocoagulation has been achieved.

13. The apparatus of claim 1 further comprising an insulator and wherein said alternating current generator serves to ohmicly heat said detachable coil and surrounding blood and tissues, but wherein local overheating is at least reduced by disposition of said insulator on at least a portion of said coil where said coil directly contacts said tissues.

14. The apparatus of claim 1 wherein said alternating current generator serves to dielectricly heat said detachable coil and surrounding blood at a radio frequency.

15. The device of claim 1 where said detachable conductive coil includes a mechanical coupling with said delivery wire and is mechanically temporarily and selectively decoupled from said delivery wire.

16. The device of claim 1 where said detachable conductive coil includes a thermally responsive coupling with said delivery wire and is temporarily and selectively decoupled from said delivery wire by use of thermal energy.

17. The device of claim 1 where said detachable conductive coil includes a optically responsive coupling with said delivery wire and is temporarily and selectively decoupled from said delivery wire by use of optical energy.

18. The device of claim 1 where said detachable conductive coil includes an electrically responsive coupling with said delivery wire and is temporarily and selectively decoupled from said delivery wire by use of electrical energy.

19. The device of claim 1 where said detachable conductive coil includes an electromagnetically responsive coupling with said delivery wire and is temporarily and selectively decoupled from said delivery wire by use of electromagnetic energy.

20. An apparatus for selectively providing endovascular occlusion in a patient comprising:

a delivery wire guidable to or near an endovascular occlusion site;

a detachable conductive coil temporarily and selectively coupled to said delivery wire, said coil being at least partially insulated to at least reduce local ohmic heating at points of contact between said coil and surrounding tissue at said occlusion site; and

an alternating current generator selectively coupled to said detachable coil for delivering RF power signals to said occlusion site, wherein said alternating current generator is a radio frequency generator which generates damped radio frequency power signals,

whereby a controllable occlusive apparatus efficacious and usable in small vessels is provided.

21. The apparatus of claim 20 further comprising a control circuit for determining when a predetermined degree of electrocoagulation has occurred at said coil and then for detaching said coil from said delivery wire.

22. An apparatus for selectively providing endovascular occlusion in a patient comprising:

a delivery wire guidable to or near an endovascular occlusion site;

a detachable conductive coil temporarily and selectively coupled to said delivery wire, said coil being at least partially insulated to at least reduce local ohmic heating at points of contact between said coil and surrounding tissue at said occlusion site; and

an alternating current generator selectively coupled to said detachable coil for delivering RF power signals to said occlusion site,

a direct current signal source electrically coupled to said detachable coil and wherein said control circuit turns said alternating current generator off when said predetermined degree of electrocoagulation has occurred and turns said direct current signal source on to detach said coil from said delivery wire,

whereby a controllable occlusive apparatus efficacious and usable in small vessels is provided.

23. A method of forming a vascular occlusion comprising:

providing a conductive delivery wire;

disposing a conductive coil coupled to said delivery wire at or near a selected occlusion site;

applying an alternating current to said coil to coagulate said occlusion site without substantial local ohmic heating between contact points between said coil and said occlusion site;

determining whether a predetermined amount of electrocoagulation has occurred at said occlusion site;

terminating said alternating current through said coil when said predetermined amount of electrocoagulation has occurred; and

detaching said coil from said delivery wire to leave said coil at said occlusion site,

whereby an occlusion is efficaciously provided in a small vessel.

24. The method of claim 23 where said coil is at least partially insulated to define insulated and noninsulated portions of said coil so that application of said alternating current to said coil is through only said noninsulated portions of said coil, said insulated portions selected to include at least one of said contact points.

25. A method of forming a vascular occlusion comprising:

providing a conductive delivery wire;

disposing a conductive coil coupled to said delivery wire at or near a selected occlusion site;

applying a damped alternating current to said coil to coagulate said occlusion site;

determining whether a predetermined amount of electrocoagulation has occurred at said occlusion site;

terminating said alternating current through said coil when said step of determining establishes that said predetermined electrocoagulation has occurred; and

detaching said coil from said delivery wire to leave said coil at said occlusion site,

whereby an occlusion is efficaciously provided in a small vessel.

26. The method of claim 25 where said damped alternating current is applied to said coil to coagulate said occlusion site in a manner to reduce ohmic heating damage to said occlusion site.