Self-setting calcium phosphate cements and methods for preparing and using them
First Claim
1. A calcium phosphate-containing composition, which self-hardens to hydroxyapatite as the predominant product at ambient temperature, comprising a calcium phosphate salt that is not tetracalcium phosphate, an additional source of slightly soluble calcium and an aqueous solution having a pH of about 12.5 or above.
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Abstract
The invention includes methods and compositions relating to calcium phosphate cements, which self-harden substantially to hydroxyapatite at ambient temperature when in contact with an aqueous medium. More specifically the cements comprise a combination of one or more sparingly soluble calcium phosphates other than tetracalcium phosphate with an aqueous solution adjusted with a base to maintain a pH of about 12.5 or above and having sufficient dissolved phosphate salt to yield a solution mixture with phosphate concentration equal to or greater than about 0.2 mol/L.
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Citations
22 Claims
- 1. A calcium phosphate-containing composition, which self-hardens to hydroxyapatite as the predominant product at ambient temperature, comprising a calcium phosphate salt that is not tetracalcium phosphate, an additional source of slightly soluble calcium and an aqueous solution having a pH of about 12.5 or above.
- 2. A calcium phosphate-containing composition, which self-hardens to hydroxyapatite as the predominant product at ambient temperature, comprising a calcium phosphate salt that is not tetracalcium phosphate, an additional source of slightly soluble calcium and an aqueous solution having a concentration of phosphate of about 0.2 mol/L or above, in the absence of solid crystalline phosphoric acid.
- 15. A kit for preparing a calcium phosphate-containing composition comprising (1) a calcium phosphate salt that is not tetracalcium phosphate, (2) an additional source of slightly soluble calcium and (3) an aqueous solution having a pH of about 12.5 or above.
- 16. A kit for preparing a calcium phosphate-containing composition comprising (1) a calcium phosphate salt that is not tetracalcium phosphate, (2) an additional source of slightly soluble calcium, and (3) an aqueous solution having a phosphate concentration of about 0.2 mol/L or above, in the absence of solid crystalline phosphoric acid.
- 17. An implant constructed in vitro for reconstruction of bone or dental tissue comprising a mixture of (1) a calcium phosphate salt that is not tetracalcium phosphate, (2) an additional source of slightly soluble calcium, and an aqueous solution having a pH of about 12.5 or above, and having a high phosphate concentration, in the absence of solid crystalline phosphoric acid whereby the mixture self-hardens to hydroxyapatite as the predominant product at ambient temperature and can be shaped as desired.
Specification