Chimeric kidney
First Claim
1. A method of increasing the nephron mass of a mammalian recipient comprising implanting at least one whole metanephros of an embryonic mammalian donor next to the recipient'"'"'s omentum or under the renal capsule of the recipient'"'"'s kidney under conditions that allow the metanephros to become vascularized, forming a chimeric kidney that produces urine and develops a ureter that facilitates externalization of the urine.
2 Assignments
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Accused Products
Abstract
Methods for increasing the nephron mass of a mammalian recipient are disclosed. A metanephros from an allogenic or xenogeneic mammalian donor is implanted next to a recipient'"'"'s omentum or under the renal capsule of the recipient'"'"'s kidney. The metanephros becomes vascularized by the recipient'"'"'s blood vessels, forming a chimeric kidney that produces urine and develops a ureter that facilitates externalization of the urine. A ureter to ureter anastomosis can be subsequently performed to provide fluid communication between the chimeric kidney ureter and a ureter of the recipient.
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Citations
16 Claims
- 1. A method of increasing the nephron mass of a mammalian recipient comprising implanting at least one whole metanephros of an embryonic mammalian donor next to the recipient'"'"'s omentum or under the renal capsule of the recipient'"'"'s kidney under conditions that allow the metanephros to become vascularized, forming a chimeric kidney that produces urine and develops a ureter that facilitates externalization of the urine.
Specification