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Water soluble paclitaxel prodrugs

  • US 5,977,163 A
  • Filed: 03/11/1997
  • Issued: 11/02/1999
  • Est. Priority Date: 03/12/1996
  • Status: Expired due to Term
First Claim
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1. A pharmaceutical composition comprising a conjugate comprising an anti-tumor or drug conjugated to a water soluble polyglutamic acid polymer, wherein said polymer has a molecular weight of greater than or equal to about 5,000, wherein said drug is conjugated to said polymer so as to provide a drug conjugate having a higher water solubility than the unconjugated drug, the ability to accumulate in a tumor, and wherein said anti-tumor drug is paclitaxel, docetaxel, etopside, teniposide, camptothecin or epothilone.

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