Optoacoustic imaging system

• US 5,977,538 A
• Filed: 05/11/1998
• Issued: 11/02/1999
• Est. Priority Date: 05/11/1998
• Status: Expired due to Fees

• Current Assignee: Cerevast Therapeutics, Inc.
• Original Assignee: Imarx Pharmaceutical Corp. (Sycamore Entertainment Group, Inc.)
• Inventors: Unger, Evan C., Wu, Yunqiu
• Primary Examiner(s): Lee, John R.
• Application Number:
  US09/075,567
• Time in Patent Office: 540 Days
• Field of Search: 250/227.11, 250/227.2, 250/227.21, 250/227.26, 73/596, 73/601, 73/603, 73/605, 73/606, 73/618, 73/620, 73/624, 73/625, 73/626, 73/627, 73/628, 73/629, 73/632, 73/641, 73/642, 73/866.1, 73/866.5, 348/163, 367/7, 367/137, 367/138, 367/191, 600/109, 600/310, 600/437, 600/440, 600/443, 600/446, 600/476
• US Class Current: 250/227.2
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence
• CPC Class Codes: A61B 8/0825 for diagnosis of the breast, e.g. mammography
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 8/5238 for combining image data of patient, e.g. merging several images from different acquisition modes into one image for image registration algorithms G06T7/30
• CPC Class Codes: G01S 15/8918 the array being linear
• CPC Class Codes: G01S 15/8922 the array being concentric or annular
• CPC Class Codes: G01S 17/89 for mapping or imaging
• CPC Class Codes: G01S 7/52074 Composite displays, e.g. split-screen displays; Combination of multiple images or of images and alphanumeric tabular information

Abstract

An optoacoustic system comprises an optoacoustic transducer including a first array of acoustic transducers and a second array of optical fibers; an acoustic subsystem for controllably exciting at least a first subset of the acoustic transducers to generate acoustic pulses with a prescribed pulse width, and for forming a first image based on return acoustic pulses reflected from a patient; an optical subsystem for controllably generating optical pulses to be transmitted through at least a first subset of the optical fibers toward the patient, and for forming a second image based on light reflected from the patient; and image correlation means for correlating the first and second images. The first and second arrays may take various forms, including the form of an annular array in which the acoustic transducers are arranged coaxially and the optical fibers are disposed around an outer periphery of the first array. The first and second arrays may also take the form of linear arrays.

Claims

1. An optoacoustic system, comprising:

(a) an optoacoustic transducer comprising a first array of accoustic transducers and a second array of optical fibers;

(b) acoustic system means coupled to said first array for controllably exciting at least a first subset of said acoustic transducers to generate acoustic pulses with a prescribed pulse width, and for forming a first image based on return acoustic pulses reflected from a patient;

(c) optical system means coupled to said second array for controllably generating optical pulses to be transmitted through at least a first subset of said optical fibers toward said patient, and for forming a second image based on light reflected from said patient; and

(d) image correlation means for correlating said first and second images.

2. A system as recited in claim 1, wherein the same acoustic transducers are used to both transmit and receive acoustic pulses to and from said patient.

3. A system as recited in claim 1, wherein said first array comprises a plurality of ultrasonic transducers.

4. A system as recited in claim 3, wherein said ultrasonic transducers are piezoelectric transducers.

5. A system as recited in claim 1, wherein said first array is an annular array in which said acoustic transducers are arranged coaxially.

6. A system as recited in claim 5, wherein said second array comprises a circular array of optical fibers disposed around an outer periphery of said first array.

7. A system as recited in claim 5, wherein said second array comprises a circular array of optical fibers disposed around an inner periphery of said first array.

8. A system as recited in claim 7, wherein said second array further comprises a bundle of optical fibers disposed within said inner periphery.

9. A system as recited in claim 1, wherein said first and second arrays are linear arrays.

10. A system as recited in claim 1, wherein said optical system means comprises means for generating pulses of light of a plurality of wavelengths, whereby tissues having different absorption characteristics will produce image features that are distinguishable from one another.

11. A system as recited in claim 10, wherein said optical system comprises multiple lasers to produce said plurality of wavelengths.

12. A system as recited in claim 10, wherein said optical system comprises a single white light source and a chopper to produce said plurality of wavelengths.

13. A system as recited in claim 1, further comprising means for simultaneously exciting groups of at least two of said acoustic transducers.

14. A system as recited in claim 13, further comprising means for sequentially exciting different groups of said acoustic transducers.

15. A system as recited in claim 1, wherein said optical system means comprises a picosecond pulser for generating optical pulses having a pulse width in the range of about 0.01 picosecond to 100 nanoseconds.

16. A system as recited in claim 15, wherein said pulse width is in the range of about 0.1 picosecond to 10 nanoseconds.

17. A system as recited in claim 1, further comprising means for providing a beam reference and trigger signal (LS₁ '"'"') indicative of the timing of the optical pulses transmitted through said first subset of said optical fibers toward said patient.

18. An optoacoustic imaging method, comprising the steps of:

(a) placing an optoacoustic transducer adjacent a body part of a patient to be imaged, said optoacoustic transducer comprising a first array of acoustic transducers and a second array of optical fibers;

(b) controllably exciting at least a first subset of said acoustic transducers to generate acoustic pulses with a prescribed pulse width, and forming a first image based on return acoustic pulses reflected from a patient;

(c) controllably generating optical pulses to be transmitted through at least a first subset of said optical fibers toward said patient, and forming a second image based on light reflected from said patient; and

(d) correlating said first and second images.

19. A method as recited in claim 18, wherein the same acoustic transducers are used to both transmit and receive acoustic pulses to and from said patient.

20. A method as recited in claim 18, wherein said first array comprises a plurality of ultrasonic transducers.

21. A method as recited in claim 20, wherein said ultrasonic transducers are piezoelectric transducers.

22. A method as recited in claim 18, wherein said first array is an annular array in which said acoustic transducers are arranged coaxially.

23. A method as recited in claim 22, wherein said second array comprises a circular array of optical fibers disposed around an outer periphery of said first array.

24. A method as recited in claim 22, wherein said second array comprises a circular array of optical fibers disposed around an inner periphery of said first array.

25. A method as recited in claim 24, wherein said second array further comprises a bundle of optical fibers disposed within said inner periphery.

26. A method as recited in claim 18, wherein said first and second arrays are linear arrays.

27. A method as recited in claim 18, wherein said step (c) comprises generating pulses of light of a plurality of wavelengths, whereby tissues having different absorption characteristics will produce image features that are distinguishable from one another.

28. A method as recited in claim 27, wherein multiple lasers are used to produce said plurality of wavelengths.

29. A method as recited in claim 27, a single white light source and a chopper are used to produce said plurality of wavelengths.

30. A method as recited in claim 18, wherein step (b) comprises simultaneously exciting groups of at least two of said acoustic transducers.

31. A method as recited in claim 30, further comprising sequentially exciting different groups of said acoustic transducers.

32. A method as recited in claim 18, wherein step (c) comprises the use of a picosecond pulser to generate optical pulses having a pulse width in the range of about 0.01 picosecond to 100 nanoseconds.

33. A method as recited in claim 32, wherein said pulse width is in the range of about 0.1 picosecond to 10 nanoseconds.

34. A method as recited in claim 18, further comprising providing a beam reference and trigger signal (LS₁ '"'"') indicative of the timing of the optical pulses transmitted through said first subset of said optical fibers toward said patient.