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Large pore synthetic polymer membranes

  • US 5,979,670 A
  • Filed: 06/11/1997
  • Issued: 11/09/1999
  • Est. Priority Date: 03/04/1994
  • Status: Expired due to Term
First Claim
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1. In a diagnostic device comprising a filtering means that delivers a filtrate that is substantially particle free containing an analyte to an analyte-detecting region of the device, the improvement comprising:

  • a filtering means comprising a polymer membrane, the membrane comprising a minimum porous surface, an opposite porous surface, and a porous supporting structure therebetween, wherein the minimum surface comprises a relatively open pore structure and the opposite surface comprises a more open pore structure and wherein the supporting structure comprises a high degree of asymmetry through at least 50% of the supporting structure but no more than 80% of the supporting structure, the membrane having surface pores at the minimum surface of a mean diameter of at least about 1.2 microns and having a flow rate of greater than about 4.5 cm/min/psi; and

    a sample application area that directs sample first to the opposite surface.

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