Apparatus and method for serial collection storage and processing of biopsy specimens

• US 5,980,468 A
• Filed: 09/22/1997
• Issued: 11/09/1999
• Est. Priority Date: 09/22/1997
• Status: Expired due to Term

• Current Assignee: David S. Zimmon
• Original Assignee: Zimmon Scientific Corporation
• Inventors: Zimmon, David S.
• Primary Examiner(s): Hindenburg, Max
• Application Number:
  US08/936,145
• Time in Patent Office: 778 Days
• Field of Search: 600/564-567, 600/569, 600/572, 606/167, 606/170, 606/184
• US Class Current: 600/567
• CPC Class Codes: A61B 10/0096 Casings for storing test samples A61B10/0038 and A61B10/0045 take precedence; preservation of living parts of the human or animal body A01N1/02; containers for retaining a material to be analysed B01L3/50; containers for enzymology or microbiology C12M1/16; swab-sampler being part of enzymology or microbiology container C12M1/30
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 10/0266 means for severing sample
• CPC Class Codes: A61B 10/0283 with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe A61B10/025, A61B10/0266 take precedence
• CPC Class Codes: A61B 10/06 Biopsy forceps , e.g. with cup-shaped jaws
• CPC Class Codes: A61B 2010/0225 for taking multiple samples

Abstract

An apparatus and method for performing a medical procedure comprising an elongated member having an aperture extending longitudinally therethrough. The member has a proximal and an opposite distal end. An actuator is positioned within the aperture and has a proximal end and an opposite distal end. Biopsy means are connected to the distal end of the actuator for cutting and collecting biopsy specimens. Either the elongated member or the distal tip is modified to receive the cut specimens in the order of acquisition. After serial acquisition, the holding segment is separated from the remainder and closed by a cap to form a processing cassette. The cassette holds the specimens in the order of acquisition through fixation and processing to be opened for slicing or analysis.

Claims

1. An apparatus for performing a medical procedure, comprising:

an elongated flexible member having an aperture extending longitudinally therethrough, said member having a proximal and an opposite distal end and a portion that is separable from said flexible member;

an actuator positioned within the aperture, said actuator having a proximal end and an opposite distal end;

biopsy means connected to the distal end of the actuator for cutting and collecting biopsy specimens; and

a cap positionable over said separable portion when said portion is removed from the flexible member, said cap closing said portion for storage and processing of biopsy specimens collected by the biopsy means in the order of collection.

2. An apparatus according to claim 1, wherein the elongated member comprises a catheter and the biopsy means comprises:

a rounded head attached to the distal end of said actuation means;

a cutting edge attached to one of said catheter and said head; and

a cutting surface attached to the other of said catheter and said head, said cutting means being actuated to cut tissue when said head is moved with respect to said catheter by said actuator.

3. An apparatus according to claim 2, wherein the head is hollow and the cap closes the head.

4. An apparatus according to claim 3, wherein the head has a length of between 2 and 4 times the diameter of the elongated member.

5. An apparatus according to claim 2, wherein the cap seals the catheter for storage and processing of biopsy specimens within the catheter.

6. An apparatus according to claim 5, further comprising a conical packing shaft on the head and extending into the catheter for packing, aligning and maintaining the position of collected biopsy specimens within the catheter.

7. An apparatus according to claim 2, wherein the actuator comprises a wire, and further comprising a stopper attached to the wire at a predetermined position, to define a storage compartment between the cap and the stopper for the biopsy specimens.

8. An apparatus according to claim 7, wherein the wire is pulled out from the cap and fixed to compress the specimens within the apparatus.

9. An apparatus according to claim 8, wherein the catheter is cut proximal to the stopper to form a capsule for the collected specimens.

10. An apparatus according to claim 3, wherein the head is perforated to allow packing of biopsy specimens by fluid injected through the catheter and permeation by fluid for fixation and processing.

11. An apparatus according to claim 2, wherein the head has a perforated flap that is peelably opened for removal of the biopsy specimens.

12. An apparatus according to claim 1, wherein the cap is perforated.

13. An apparatus according to claim 1, wherein the biopsy means comprises a spring jaw having a cutting tool, said spring jaw being remotely deployable from said flexible member, and an internal jaw guide in the distal end of said member, said jaw guide contacting along said jaw for controlling the precise movement of said jaw and defining a cavity within said member for receiving a substantial portion of said jaw.

14. An apparatus according to claim 13, wherein the member is a catheter and the spring jaw and jaw guide are elongated to form a chamber within the catheter for serial acquisition, storage and processing of specimens within the chamber.

15. An apparatus according to claim 14, wherein the catheter is a plastic extrusion having a large central lumen and two smaller side lumens.

16. An apparatus according to claim 15, wherein the side lumens are connected via slits to the central lumen and act as a suction means to draw the biopsy specimens into the chamber in order of acquisition after each biopsy.

17. An apparatus according to claim 16, wherein the cap is perforated, and the catheter is cut proximal to the chamber and closed with the cap.

18. An apparatus according to claim 13, further comprising a second cap for closing the distal end of the flexible member after collection of biopsies.

19. A method for the serial collection, storage and processing of biopsy specimens, comprising

cutting at least one specimen with a biopsy means deployed from an elongated hollow member;

placing said specimen within said elongated hollow member in order of collection;

removing said biopsy means from said elongated member; and

closing said elongated member with at least one perforated cap, to create a processing cassette for said specimens.

20. The method according to claim 19, further comprising compressing said specimens within said elongated hollow member and cutting said member to create a compact processing cassette.

21. A method for the serial collection, storage and processing of biopsy specimens, comprising

cutting at least one specimen with a biopsy means on an apparatus having a hollow head;

placing said specimen within said hollow head in order of collection;

removing the hollow head from the apparatus; and

closing the hollow head with a perforated cap to create a processing cassette for said specimens.