Topical drug dispersing apparatus

• US 5,980,496 A
• Filed: 12/11/1997
• Issued: 11/09/1999
• Est. Priority Date: 12/11/1997
• Status: Expired due to Fees

• Current Assignee: Sterling Investments LC, School of Pharmacy (University of Nottingham)
• Original Assignee: SARCOS LC (Sarcos Technology & Robotics Corp.)
• Inventors: Jacobsen, Stephen C., Davis, Clark
• Primary Examiner(s): Coggins, Wynn Wood
• Assistant Examiner(s): Bianco, Patricia
• Application Number:
  US08/988,944
• Time in Patent Office: 698 Days
• Field of Search: 604/20, 604/131, 604/151, 604/289, 604/304, 604/305, 604/308, 119/650, 119/652, 119/653, 119/654, 119/655, 119/858, 119/860
• US Class Current: 604/289
• CPC Class Codes: A01K 27/007 with insecticide-dispensing means
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04

Abstract

The method for automatic dosing of drugs utilizes a delivery device which may be administered to an animal. The delivery device is configured to have one or more compartments or reservoirs, each containing at least one drug so that a plurality of doses of the drug(s) are held within the device. In accordance with the present invention, the delivery device selectively releases doses of the drug(s) to provide an efficacious dosing pattern. One primary function of the present invention is to release two or more pesticides in such a pattern that parasites are effectively controlled while preventing the development of tolerance to the drugs within the parasites. Preferably, the delivery device is programmable to effectuate the release of the drug(s) at a desired time to maintain efficacious levels of the drug while minimizing the amount of drug which must be used.

Claims

1. An apparatus for the delivery of at least one drug to an animal, comprising:

a support structure securable to a body part of an animal;

a first reservoir secured to the support structure and containing at least one drug therein;

a first delivery device in fluid communication with the reservoir; and

a topical dispenser comprising a pad having an irregular contact surface exposed on a side of the support structure to be in substantial contact with an animal wearing the support structure, said dispenser being in fluid communication with the delivery device, whereby activation of the at least one delivery device transfers the at least one drug from the reservoir to the dispenser.

2. The apparatus of claim 1, wherein the support structure comprises a collar with the reservoir, the delivery device, and the dispenser disposed thereon.

3. The apparatus of claim 1, wherein the irregular contact surface of the pad comprises a plurality of concentric ribs extending from a surface thereof and defining a plurality of grooves thereinbetween.

4. The apparatus of claim 3, wherein said delivery device is in fluid communication with a center portion of the pad for dispensing the at least one drug contained in the reservoir through the center portion of the pad.

5. The apparatus of claim 1, wherein the irregular contact surface of the pad comprises at least one of a plurality of walls defining a plurality of grooves thereinbetween, a plurality of raised portions defining a plurality of lowered portions, and a plurality of nubs.

6. The apparatus of claim 2, wherein the dispenser is substantially contained within the collar.

7. The apparatus of claim 1, further including a second reservoir and a second delivery device in fluid communication with the dispenser.

8. The apparatus of claim 7, wherein the second reservoir contains at least one other drug of different composition than the at least one drug contained in the first reservoir.

9. An apparatus for the delivery of at least one drug to an animal, comprising:

a collar mountable about a body portion of an animal;

a pump secured to said collar, said pump having an inlet and an outlet;

a drug reservoir in fluid communication with said inlet of said pump; and

a dispensing device comprising a pad having an irregular contact surface exposed on a side of the support structure to be in substantial contact with said animal wearing the support structure, said dispenser being in fluid communication with said outlet of said pump.

10. A method of delivering at least one drug to an animal, comprising:

attaching a drug delivery system comprising a support structure securable to a body part of an animal, a first reservoir secured to the support structure and containing at least one drug therein, a first delivery device in fluid communication with the reservoir, and a topical dispensing pad having an irregular contact surface exposed on a side of the support structure to be in substantial contact with an animal wearing the support structure, said dispenser being in fluid communication with the delivery device and in at least partial contact with the animal;

programming the drug delivery system to dispense the at least one drug to the topical dispensing pad according to a desired dosing regimen;

actuating the drug delivery system to dispense doses of the at least one drug to the dispensing pad in accordance with the desired dosing regimen, each of said doses being of an amount that can be adequately contained within the topical dispensing pad.

11. The method of claim 10, wherein said doses are spaced an amount sufficient to adequately ensure that a prior dose has been sufficiently delivered to the animal.

12. The method of claim 10, further including at least one other drug, and said drug delivery system dispensing said at least one other drug to the topical dispensing pad.

13. The method of claim 10, wherein an initial dose is a loading dose of the at least one drug.

14. The method of claim 13, wherein subsequent doses are maintenance doses of an amount less than the initial dose.

15. The method of claim 10, wherein said at least one drug is selected from a parasiticide for the control of at least one of an ectoparasite and endoparasite.

16. The method of claim 15, wherein said at least one drug is selected from the group comprising permethrin and ivermectin.

17. The method of claim 10, wherein said at least one drug is selected from the group comprising antibiotics, antivirals, and antifungals.

18. The method of claim 10, wherein each of said doses are provided at preprogrammed intervals to ensure that a level of drug in the animal stays above an efficacy level of the at least one drug.

19. The method of claim 12, wherein a first dose of the at least one drug is dispensed to the topical dispensing pad and a first dose of the at least one other drug is dispensed to the topical dispensing pad at a first predetermined time after the first dose of the at least one drug.

20. The method of claim 19, wherein the method further comprises delivering additional doses of the at least one drug and the at least one other drug in an alternating fashion, each dose being spaced a predetermined period of time.