Water-soluble coating for bioactive vasoocclusive devices

• US 5,980,550 A
• Filed: 06/18/1998
• Issued: 11/09/1999
• Est. Priority Date: 06/18/1998
• Status: Expired due to Term

• Current Assignee: Target Therapeutics, Inc. (Boston Scientific Corporation)
• Original Assignee: Target Therapeutics, Inc. (Boston Scientific Corporation)
• Inventors: Olson, Stanley W. Jr., Eder, Joseph C., Slaikeu, Paul C., Abrams, Robert M
• Primary Examiner(s): Buiz, Michael
• Assistant Examiner(s): HO, TAN-UYEN THI
• Application Number:
  US09/100,426
• Time in Patent Office: 509 Days
• Field of Search: 606/191, 606/190, 606/151, 606/108, 606/198, 606/1
• US Class Current: 606/191
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated

Abstract

A vaso-occlusive device having a bioactive inner coating and a water-soluble outer coating. Methods of preparing the devices are also provided.

Claims

1. A vaso-occlusive device comprising:

a) a vaso-occlusive member;

b) an inner bioactive coating on said vaso-occlusive member; and

c) an outer coating on said inner coating, said outer comprising a water-soluble agent.

2. The device of claim 1, wherein the vaso-occlusive member is a metallic element comprising an elongated helical coil.

3. The device of claim 2 wherein the coil is a cylindrical helical coil.

4. The device of claim 2 wherein the coil comprises a metal selected from gold, rhenium, platinum, palladium, rhodium, ruthenium, stainless steel, tungsten and alloys thereof.

5. The device of claim 1 wherein the inner bioactive coating is a thrombogenic or therapeutic agent.

6. The device of claim 5 wherein the inner bioactive coating is permanently bonded to said vaso-occlusive member.

7. The device of claim 6 wherein the inner bioactive coating is selected from the group consisting of collagen, fibrinogen, growth factors and synthetic peptides.

8. The device of claim 6 wherein the inner bioactive coating is created by plasma treatment.

9. The device of claim 1 wherein said outer coating is a water-soluble anti-thrombogenic agent.

11. The device of claim 1 wherein said outer coating further comprises a component that affects the solubility of said outer coating.

12. The device of claim 1 further comprising an overcoating on said outer coating of a component that affects the solubility of said outer coating.

13. The device of claim 1 wherein the water-soluble agent dissolves shortly after said vaso-occlusive member is deployed.

14. The device of claim 1 wherein the inner and outer coatings do not affect the shape of said vaso-occlusive member after deployment.

10. The device of claim 10 wherein the outer coating is selected from the group consisting of acetyl salicylic acid, heparin, coumadin and alnert.

15. A method for treating a vaso-occlusive device comprising

(a) providing an inner coating for a vaso-occlusive device comprising a bioactive material;

and

(b) providing an outer coating over said inner coating, said outer coating comprising a water-soluble material.

16. The method of claim 15 where the vaso-occlusive device comprises a metallic element.

17. The method of claim 15 where the metallic element comprises a helically wound coil.

18. The method of claim 15 where the helically wound coil comprises a metal selected from gold, rhenium, platinum, palladium, rhodium, ruthenium, stainless steel, tungsten and alloys thereof.

19. The method of claim 15 wherein the outer coating is selected from the group consisting of acetyl salicylic acid, heparin, coumadin and alnert.

20. The method of claim 15 wherein the outer coating further comprises a component which affects the solubility of said outer coating.

21. The product produced by the process of claim 15.