High glycerin containing anti-microbial cleansers

• US 5,980,925 A
• Filed: 12/30/1997
• Issued: 11/09/1999
• Est. Priority Date: 12/30/1997
• Status: Expired due to Term

• Current Assignee: Schulke & Mayr GmbH
• Original Assignee: Ethicon Incorporated (Johnson & Johnson)
• Inventors: Jampani, Hunuman B., Newman, Jerry L.
• Primary Examiner(s): Dees, Jose' G.
• Assistant Examiner(s): Shelborne, Kathryne E.
• Application Number:
  US09/001,020
• Time in Patent Office: 679 Days
• Field of Search: 424/405, 424/401, 424/404, 424/70.12, 424/78.03, 510/426, 510/235, 514/844, 514/937, 514/943, 514/944
• US Class Current: 424/405
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 8/345 containing more than one hydroxy group
• CPC Class Codes: A61K 8/43 Guanidines
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations

Abstract

Emulsions containing a dermal anchoring/substantive agent, such as glycerin, in high concentration enhance the activity of active ingredients, such as anti-microbial agents like chlorhexidine gluconate. Kits, compositions and methods pertaining to the same are provided. The invention finds application in cleansers such as hand washes, wound cleansers, body washes, mouthwashes, surgical scrubs, etc., and lotions, creams, foams and ointments. Specifically, one embodiment of the emulsion contains greater than 30% of an anchoring/substantive agent such as glycerin and an effective amount of chlorhexidine gluconate. Additionally, the product produced by the process of combining on the skin high glycerin and an anti-microbial is described.

Claims

1. A wash solution comprising:

(a) more than 30% of an anchoring agent,

wherein the anchoring agent is selected from the group consisting of 3 to 6 carbon polyols, 3 to 6 carbon aldoses, and 3 to 6 carbon ketoses, and their combinations and derivatives;

(b) from about 0.01% to about 10% active ingredient,

wherein the active ingredient is selected from the group consisting of anti-histamines, anti-inflammatory agents, analgesics, anesthetics, anti-perspirants, anti-dandruffs, anti-microbial agents, astringents, counter-irritants, depigmenting agents, bleaching agents, and steroids.

2. The wash solution of claim 1, wherein the active ingredient is an anti-microbial agent.

3. The wash solution of claim 1, wherein the anchoring agent is a 3 to 6 carbon polyol.

4. The wash solution of claim 3, wherein the polyol is a polyol which has a backbone of 3 to 6 carbons and at least two hydroxyl groups.

5. The wash solution of claim 4, wherein the active agent is an anti-microbial agent.

6. The wash solution of claim 5,

wherein the polyol is selected from the group consisting of glycerin, propylene glycol, butylene glycol and combinations thereof;

and

wherein the anti-microbial agent is a chlorhexidine derivative.

7. The wash solution of claim 5,

wherein the polyol is glycerin;

and

wherein the anti-microbial agent is chlorhexidine gluconate.

8. The wash solution of claim 3,

wherein the 3 to 6 carbon polyol is selected from the group consisting of glycerin, propylene glycol, 1,3-butylene glycol, 2,3-butylene glycol and combinations thereof;

and

wherein the active ingredient is an anti-microbial agent selected from the group consisting of chlorhexidine gluconate, chlorhexidine digluconate, chlorhexidine diacetate, chlorhexidine dihydrochloride and combinations thereof.

9. The wash solution of claim 5,

wherein the anti-microbial agent is a chlorhexidine derivative.

10. The wash solution of claim 9,

wherein the chlorhexidine derivative is chlorhexidine gluconate.

11. The wash solution of claim 5,

wherein the anti-microbial agent is nisin.

12. The wash solution of claim 5,

wherein the anchoring agent is selected from the group consisting of glycerol, propylene glycol, glyceraldehyde, dihydroxyacetone, 1,3-butylene glycol, 2,3-butylene glycol, erythritol, erythrose, erythrulose, sorbitol, mannitol, and inositol;

and

wherein the anti-microbial agent is selected from the group consisting of nisin, bis-diguanides, chlorhexidine gluconate, chlorhexidine digluconate, chlorhexidine diacetate, chlorhexidine dihydrochloride, polyhexamethylene biguanide, benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetyl pyridinium chloride, triclosan, triclocarban, tribromsalan, amyltricresols, parachlorometaxylenol, phenol, iodine, nonylphenoxypoly (ethyleneoxy) ethanoliodine, poloxamer-iodine complex, undecoylium chloride iodine complex, bisquaternary ammonium compounds, polymeric quaternary ammonium compounds, cationic peptides, organometallic antiseptics, alkyl pyridinium salts, essential oils, ethanol, propanol, butanol, pentanol, 2-methyl-1-butanol, hexanol, 2-methyl-1-pentanol, 3-methyl-1-pentanol, 2-ethyl-1-butanol, 3,5,5-trimethyl-10-hexanol, heptanol, octanol, isooctyl alcohol, decanol, dodecanol, tridecanol, tetradecanol and their combinations and derivatives.

13. The wash solution of claim 1, further comprising an agent selected from the group consisting of octadecene-1/maleic anhydride copolymer, organofluorinated modified silicone resins, polyvinyl pyrrolidone, hydrogenated copolymers of styrene and butadiene, film forming copolymers, copolymers of eicosene and vinyl pyrrolidone, copolymer of hexadecane and vinyl pyrrolidone, cellulosic ethers, 2-hydroxyethyl methacrylate homopolymer, cocodimethyl ammonium salt of hydrolyzate of wheat protein, guar hydroxy propyltrimonium chloride, hydroxypropylcellulose, lauryldimonium hydroxypropyl hydrolyzed collagen, lauryldimonium hydroxypropyl hydrolyzed wheat protein, polyquaternium-24 and hyaluronic acid, soluble reticulin and soluble wheat protein, stearyldimonium hydroxypropyl hydrolyzed collagen, acrylic/acrylate copolymers, Behenoxy dimethicone, dimethicone copolyol phosphate, polydecene/polybutene copolymer, polymethacrylamidopropyl trimonium chloride, and polymethylalkyl siloxane.

14. The wash solution of claim 1,

wherein the anchoring agent is present in an amount of at least 40% of the wash solution.

15. The wash solution of claim 1, wherein the anchoring agent is present in an amount ranging from about 40% to about 80% of the wash solution.

16. The wash solution of claim 15, wherein the anti-microbial agent is present in an amount ranging from about 0.01% to about 5% of the wash solution.

17. The wash solution of claim 16, wherein the anchoring agent is glycerin and the anti-microbial agent is chlohexidine gluconate.

18. A method of improving the efficacy of a polar anti-microbial agent on the skin, said method comprising the steps of:

treating the skin with a composition containing more than 30% of an anchoring agent; and

washing the skin with an anti-microbial agent.

19. The method of claim 18,

wherein the anchoring agent is selected from the group consisting of glycerol, propylene glycol, glyceraldehyde, dihydroxyacetone, 1,3-butylene glycol, 2,3-butylene glycol, erythritol, erythrose, erythrulose, sorbitol, mannitol, and inositol;

and

wherein the anti-microbial agent is selected from the group consisting of nisin, bis-diguanides, chlorhexidine gluconate, chlorhexidine digluconate, chlorhexidine diacetate, chlorhexidine dihydrochloride, polyhexamethylene biguanide, benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetyl pyridinium chloride, triclosan, triclocarban, tribromsalan, amyltricresols, parachlorometaxylenol, phenol, iodine, nonylphenoxypoly (ethyleneoxy) ethanoliodine, poloxamer-iodine complex, undecoylium chloride iodine complex, bisquaternary ammonium compounds, polymeric quaternary ammonium compounds, cationic peptides, organometallic antiseptics, alkyl pyridinium salts, essential oils, ethanol, propanol, butanol, pentanol, 2-methyl-1-butanol, hexanol, 2-methyl-1-pentanol, 3-methyl-1-pentanol, 2-ethyl-1-butanol, 3,5,5-trimethyl-10-hexanol, heptanol, octanol, isooctyl alcohol, decanol, dodecanol, tridecanol, tetradecanol and their combinations and derivatives.

20. The method of claim 18, wherein the anchoring agent is glycerin and the anti-microbial agent is a chlorhexidine derivative or nisin.

21. The method of claim 18, wherein the first step is the step of washing with the anti-microbial agent.

22. The method of claim 18, wherein the first step is the step of treating the skin with the composition containing the anchoring agent.

23. A kit used for the anti-microbial treatment of skin, said kit comprising:

a first composition comprising more than 30% of an anchoring agent,

wherein the anchoring agent is selected from the group consisting of 3 to 6 carbon polyols, 3 to 6 carbon aldoses, and 3 to 6 carbon ketoses, and their combinations and derivatives; and

a second composition comprising from about 0.1% to about 50% of an anti-microbial agent,

wherein the anti-microbial agent is selected from the group consisting of nisin, bis-diguanides, chlorhexidine gluconate, chlorhexidine digluconate, chlorhexidine diacetate, chlorhexidine dihydrochloride, polyhexamethylene biguanide, benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetyl pyridinium chloride, triclosan, triclocarban, tribromsalan, amyltricresols, parachlorometaxylenol, phenol, iodine, nonylphenoxypoly (ethyleneoxy) ethanoliodine, poloxamer-iodine complex, undecoylium chloride iodine complex, bisquaternary ammonium compounds, polymeric quaternary ammonium compounds, cationic peptides, organometallic antiseptics, alkyl pyridinium salts, essential oils, ethanol, propanol, butanol, pentanol, 2-methyl-1-butanol, hexanol, 2-methyl -1-pentanol, 3-methyl-1-pentanol, 2-ethyl-1-butanol, 3,5,5-trimethyl-10-hexanol, heptanol, octanol, isooctyl alcohol, decanol, dodecanol, tridecanol, tetradecanol and their combinations and derivatives.

24. The kit of claim 23, wherein the anchoring agent is glycerin and the anti-microbial agent is a chlorhexidine derivative or nisin.

25. A product produced by the process of:

treating the skin with a first composition containing more than 30% of an anchoring agent,

wherein the anchoring agent is selected from the group consisting of 3 to 6 carbon polyols, 3 to 6 carbon aldoses, and 3 to 6 carbon ketoses, and their combinations and derivatives; and

treating said skin with a second composition containing from about 0.1 to about 50% of an anti-microbial agent,

wherein the anti-microbial agent is selected from the group consisting of nisin, chlorhexidine gluconate, chlorhexidine digluconate, chlorhexidine diacetate, chlorhexidine dihydrochloride, benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetyl pyridinium chloride, triclosan, triclocarban, tribromsalan, amyltricresols, parachlorometaxylenol, phenol, iodine, nonylphenoxypoly (ethyleneoxy) ethanoliodine, poloxamer-iodine complex, undecoylium chloride iodine complex, bisquaternary ammonium compounds, polymeric quaternary ammonium compounds, cationic peptides, organometallic antiseptics, alkyl pyridinium salts, essential oils, ethanol, propanol, butanol, pentanol, 2-methyl-1-butanol, hexanol, 2-methyl-1-pentanol, 3-methyl-1-pentanol, 2-ethyl-1-butanol, 3,5,5-trimethyl-10-hexanol, heptanol, octanol, isooctyl alcohol, decanol, dodecanol, tridecanol, tetradecanol and their combinations and derivatives.

26. The product of claim 25, wherein the anchoring agent is glycerin and the anti-microbial is a chlorhexidine derivative.