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Hydrophilic metal complexes

  • US 5,981,286 A
  • Filed: 01/16/1997
  • Issued: 11/09/1999
  • Est. Priority Date: 07/25/1994
  • Status: Expired due to Term
First Claim
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1. A metal complex having the formula:

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    space="preserve" listing-type="equation">[M(L.sub.1 L.sub.2 L.sub.3)].sub.n --X.sub.m AwhereinM is a divalent or trivalent metal cation selected from the group consisting of a rare earth metal cation and a transition metal cation;

    L1, L2 and L3 are the same or different, and each is a ligand having at least two nitrogen-containing heterocyclic rings, wherein L1, L2 and L3 are bound to the metal cation via nitrogen atoms;

    X is a reactive or activatable functional group selected from the group consisting of an activated carboxylic acid group, a maleimide, a carboxylic acid, a thiol, a halide and a photoactivatable group;

    n is 1 to 10;

    m is 1 to 6; and

    A is at least one negatively charged group,wherein the metal complex contains at least one hydrophilic group selected from the group consisting of a C2 -C3 alkyleneoxy group, a C2 -C3 alkylenethio group, a C2 -C3 alkyleneamino group and a polyhydroxy group, wherein the at least one hydrophilic group is located at at least one of the following locations (a) and (b);

    (a) as a substituent or component of a substituent of one of the ligands L1, L2 and L3 ; and

    (b) as a linker or component of a linker which links the group X and one of the ligands L1, L2 and L3.

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