Differentiating agents for the treatment of inflammatory intestinal diseases

• US 5,981,597 A
• Filed: 03/30/1995
• Issued: 11/09/1999
• Est. Priority Date: 02/13/1995
• Status: Expired due to Fees

• Current Assignee: Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Original Assignee: Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Inventors: Wu, Gary Dean
• Primary Examiner(s): Kunz, Gary L.
• Application Number:
  US08/413,806
• Time in Patent Office: 1,685 Days
• Field of Search: 514/786, 514/557, 514/616, 536/4.1
• US Class Current: 514/616
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/192 having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid cannabinoids A61K31/658
• CPC Class Codes: A61K 31/22 of acyclic acids, e.g. pravastatin
• CPC Class Codes: C07C 53/122 Propionic acid
• CPC Class Codes: C07C 53/124 Acids containing four carbon atoms
• CPC Class Codes: C07C 57/32 Phenylacetic acid
• CPC Class Codes: C07K 14/5421 IL-8

Abstract

A method for decreasing the inflammation associated with a chronic inflammatory intestinal condition in a patient is provided wherein the patient is administered an effective amount of a differentiating agent.

Claims

1. A method for decreasing the elevated levels of interleukin-8 in chronic inflammatory intestinal conditions comprising administering an effective amount of a differentiating agent selected from the group consisting of sodium proprionate and hexamethylene bisacetamide.