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Electrotransport agent delivery method and apparatus

  • US 5,983,130 A
  • Filed: 06/07/1995
  • Issued: 11/09/1999
  • Est. Priority Date: 06/07/1995
  • Status: Expired due to Term
First Claim
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1. In an electrotransport device for delivering a therapeutic agent through a body surface, the delivery device having a source of electrical power, a counter electrode, and a donor reservoir containing the agent, the reservoir having a delivery area through which the agent is delivered through the body surface, the improvement comprising;

  • an applied electrotransport current controller, the controller being adapted to apply a pulsating electrotransport current to the reservoir and in turn to the body surface, each pulse of the pulsating current being characterized by a frequency, a duty cycle, a peak width, and a peak current, the peak current when divided by the area of the delivery area providing a peak current density, Imax, Imax being greater than a critical current density level, Ic, above which the body surface exhibits non-transitory higher agent delivery efficiency (E), the delivery efficiency (E) being equal to the rate of agent delivered through the body surface per unit of applied electrotransport current.

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