Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy

• US 5,984,882 A
• Filed: 12/16/1997
• Issued: 11/16/1999
• Est. Priority Date: 08/19/1996
• Status: Expired due to Fees

• Current Assignee: Angiosonics, Inc. (Acolysis Intravascular Ultrasound Business) (Teleflex Incorporated)
• Original Assignee: Angiosonics, Inc. (Acolysis Intravascular Ultrasound Business) (Teleflex Incorporated)
• Inventors: Rozenszajn, Arie, Rosenschein, Uri
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US08/991,948
• Time in Patent Office: 700 Days
• Field of Search: 601/2, 601/3, 604/22, 600/639, 600/1, 600/2
• US Class Current: 601/2
• CPC Class Codes: A61B 17/22012 in direct contact with, or very close to, the obstruction or concrement for removing obstructions in blood vessels by laser A61B18/245
• CPC Class Codes: A61B 2017/22002 preventing restenosis
• CPC Class Codes: A61B 2017/22014 the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire not applied in A61B17/22012
• CPC Class Codes: A61B 2017/320073 probe
• CPC Class Codes: A61B 2017/320089 node location
• CPC Class Codes: A61B 2018/00011 with fluids
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: G10K 11/24 for conducting sound through solid bodies, e.g. wires

Abstract

A device and methods for inducing apoptosis in precancerous, cancerous and hyperproliferating cells by applying ultrasonic energy. The methods can include use of ultrasonic energy in combination with antioxidants and/or conventional therapies such as hormonal therapy, radiation therapy or chemotherapy. The device for the ultrasonic energy source can include a transmitter and a control unit.

Claims

1. A method of preventing development of cancer in an individual having a region of aging or precancerous cells, the method comprising applying in the region of aging or precancerous cells an effective amount of ultrasonic energy of sufficient dosage to induce apoptosis of the aging or precancerous cells.

2. The method according to claim 1, wherein the dosage of ultrasonic energy supplied is above at least 22.5 watt/sec and the cavitation threshold of blood.

3. The method according to claim 1, wherein the ultrasonic energy supplied has a frequency in the range of about 1 kHz to about 3 MHz.

4. The method according to claim 1, wherein the ultrasonic energy supplied has a frequency in the range of about 15 kHz to about 250 kHz.

5. The method of claim 1, wherein ultrasonic energy is applied with an ultrasonic energy source for providing ultrasonic energy, a transmitter for transmitting the ultrasonic energy to the region of the aging or precancerous cells, and a control unit controlling the ultrasonic energy source, the ultrasonic energy source, the transmitter and the control unit being constructed and arranged to transmit the ultrasonic energy to the aging or precancerous cells in an amount sufficient to induce apoptosis of the aging or precancerous cells present in the region.

6. A method of treating cancer in an individual, comprising applying to an individual having cancer cells in a region of the body, ultrasonic energy in the region of the cancer with an effective amount of ultrasonic energy to induce apoptosis of the cancer cells.

7. The method according to claim 6, wherein the ultrasonic energy supplied is above at least 22.5 watt/sec and the cavitation threshold of blood.

8. The method according to claim 6, wherein the ultrasonic energy supplied has a frequency in the range of about 1 kHz to about 3 MHz.

9. The method according to claim 6, wherein the ultrasonic energy supplied has a frequency in the range of about 15 kHz to about 250 kHz.

10. The method according to claim 6, wherein applying ultrasound in the region of the cancer occurs after surgical removal of the cancer.

11. The method according to claim 6, comprising administration of an antioxidant.

12. The method according to claim 6, comprising administration of an effective amount of at least one antioxidant selected from the group consisting of vitamin E, N-acetylcysteine, glutathione, vitamin C, cysteine, methionine, 2-mercaptoethanol and photosensitizing molecules.

13. The method according to claim 6, comprising administration of an effective amount of hormonal therapy.

14. The method according to claim 6, comprising administration of an effective amount of radiation therapy.

15. The method according to claim 6, comprising administration of an effective amount of at least one chemotherapeutic agent.

16. The method according to claim 15, comprising administration of an effective amount of ultrasonic energy to accelerate the delivery of the chemotherapeutic agent to a target.

17. The method of claim 6, wherein ultrasonic energy is applied with an ultrasonic energy source for providing ultrasonic energy, a transmitter for transmitting the ultrasonic energy to the region of the cancer cells, and a control unit controlling the ultrasonic energy source, the ultrasonic energy source, the transmitter and the control unit being constructed and arranged to transmit the ultrasonic energy to the cancer cells in an amount sufficient to induce apoptosis of the cancer cells present in the region.

18. A method of treating arteriosclerosis in an individual having arteriosclerosis, comprising applying ultrasonic energy to smooth muscle cells in the region of an atheromatous plaque in the vessel wall with an effective amount of ultrasonic energy to induce apoptosis of the smooth muscle cells.

19. A method according to claim 18, comprising administration of an antioxidant.

20. The method according to claim 18, comprising administration of at least one antioxidant selected from the group consisting of vitamin E, N-acetylcysteine, glutathione, vitamin C, cysteine, methionine, 2 mercaptoethanol and photosensitizing molecules.

21. A method of preventing or treating cell proliferative diseases comprising applying ultrasonic energy in the region of proliferating cells with an effective amount of ultrasonic energy to induce apoptosis of the proliferating cells.

22. The method according to claim 21, wherein the cell proliferative diseases are selected from the group consisting of eczema, psoriasis, retinopathies, vascular diseases and fibrotic diseases.

23. A method of inducing apoptosis in a cell expressing a growth factor receptor, the method comprising applying ultrasonic energy with an effective amount to induce apoptosis in the cell.

24. A method according to claim 23, wherein the growth factor receptor is selected from the group consisting of EGF, TGF, NGF, FGF, IGF or PDGF.