Method for increasing the service life of an implantable sensor

• US 5,985,129 A
• Filed: 04/28/1992
• Issued: 11/16/1999
• Est. Priority Date: 12/14/1989
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Gough, David A., Lucisano, Joseph Y.
• Primary Examiner(s): TUNG, TA HSUNG
• Application Number:
  US07/874,697
• Time in Patent Office: 2,758 Days
• Field of Search: 204/147, 204/148, 204/196, 204/197, 204/153.1, 204/153.12, 204/153.17, 204/400, 204/402, 204/403, 204/412, 204/415, 204/435, 204/196.1, 205/775, 205/777.5, 205/778, 205/782, 205/782.5, 205/792, 205/724
• US Class Current: 205/724
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: Y10S 128/903 Radio telemetry

Abstract

Methods are described for extending the service life of implantable sensors having a silver-containing anodic reference electrode maintained at a high impedance, at least one noble metal cathodic working electrode, and at least one noble metal anodic counter electrode maintained at a low impedance, particularly sensors for the in vivo detection of oxygen and/or glucose in bodily fluids. The methods described involve increasing the input impedance of the reference electrode up to a maximum for implanted circuitry and shielding said electrode, and/or alternating the operating roles of the reference and working electrodes, switching the working electrodes with counter electrodes in the circuit, reversing the polarities of the reference and working electrodes, and sequentially activating each electrode in a plurality of working and/or reference electrodes in the circuit. All of the circuitry means needed to control the steps described can be implanted with the sensor so that the steps can be performed while the sensor is in use in a patient.

Claims

1. A method for extending the service life of implantable sensors containing corrodible electrodes within a potentiostat sensor circuit having a sensor having a corrodible reference electrode, at least one noble metal cathodic working electrode, and at least one noble-metal anodic counter electrode maintained at a low impedance, which comprises applying to said reference electrode a continuous cathodic current.

2. A method according to claim 1 for extending the service life of implantable sensors containing corrodible electrodes within a potentiostat sensor circuit having a sensor having a corrodible reference electrode, at least one noble metal cathodic working electrode, and at least one noble metal anodic counter electrode maintained at a low impedance, which comprises increasing the input impedance at the reference electrode and shielding said reference electrode.

3. A method according to claim 1 wherein said corrodible electrode is a silver or silver-impregnated electrode.