Device and method for non-occlusive localized drug delivery
First Claim
1. A removable, expandable, non-occlusive endovascular support device adapted for providing prolonged localized delivery of a therapeutic agent to a preselected site within a blood vessel, comprising:
- a. an inflatable, elongated, tubular-shaped balloon having a proximal end, a distal end and a central lumen therethrough, the tubular-shaped balloon having an inflation chamber defined by;
i. a medial exterior wall defining the central lumen;
ii. an opposite lateral exterior wall; and
iii. the opposed proximal and distal ends;
b. chamber inflation means in fluid connection with the inflation chamber; and
c. therapeutic agent delivery means located on a selected one of the medial exterior wall or the lateral exterior wall.
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Accused Products
Abstract
A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without substantially disrupting the fluid flow therethrough. For example, an indwelling endovascular support device is provided for delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.
533 Citations
65 Claims
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1. A removable, expandable, non-occlusive endovascular support device adapted for providing prolonged localized delivery of a therapeutic agent to a preselected site within a blood vessel, comprising:
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a. an inflatable, elongated, tubular-shaped balloon having a proximal end, a distal end and a central lumen therethrough, the tubular-shaped balloon having an inflation chamber defined by; i. a medial exterior wall defining the central lumen; ii. an opposite lateral exterior wall; and iii. the opposed proximal and distal ends; b. chamber inflation means in fluid connection with the inflation chamber; and c. therapeutic agent delivery means located on a selected one of the medial exterior wall or the lateral exterior wall. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A removable, expandable, adapted for providiascular support device adapted for providing prolonged localized delivery of a therapeutic agent to a preselected site within a blood vessel, comprising:
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a. an inflatable, elongated, tubular-shaped balloon having a proximal end, a distal end and a central lumen therethrough, comprising; i. a medial chamber comprised of a medial exterior wall defining the central lumen and an opposite dividing wall interconnected at the proximal and distal ends, and ii. a lateral chamber coaxially disposed about the medial chamber comprised of the dividing wall, and an opposite lateral exterior wall interconnected at the proximal and distal ends; b. medial chamber inflation means in fluid connection with the medial chamber; c. lateral chamber inflation means in fluid connection with the lateral chamber; and d. therapeutic agent delivery means located on a selected one of the medial exterior wall or the lateral exterior wall. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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61. A removable, non-occlusive, endovascular support device adapted for prolonged localized delivery of a therapeutic agent at a preselected site within a blood vessel, comprising:
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a. a tubular-shaped, dual-chambered, expandable member having a proximal end, a distal end, an exterior surface and an interior surface defining a central lumen therethrough, comprising; i. a support chamber formed from a plurality of inflatable interconnecting inflation cells; and ii. a tubular-shaped therapeutic agent delivery chamber interspersed between the inflation cells and having an outside surface with a medial face and a lateral face defined by the exterior and interior surfaces respectively of the tubular-shaped member; b. support chamber inflation means in fluid connection with the support chamber; c. a therapeutic agent delivery tube in fluid connection with the therapeutic agent delivery chamber; and d. therapeutic agent delivery means located on a selected one of the medial or lateral surfaces of the therapeutic agent delivery chamber. - View Dependent Claims (62, 63, 64, 65)
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Specification