Process for producing anti-microbial effect with complex silver ions

• US 5,985,308 A
• Filed: 02/02/1994
• Issued: 11/16/1999
• Est. Priority Date: 05/19/1992
• Status: Expired due to Term

• Current Assignee: NUCRYST Pharmaceuticals Corp. (The Westaim Corporation)
• Original Assignee: Westaim Technologies Inc.
• Inventors: Apte, Prasad Shrikrishna, Burrell, Robert Edward, Morris, Larry Roy, Precht, Roderick John, Gill, Kashmir Singh
• Primary Examiner(s): Azpuru, Carlos
• Application Number:
  US08/190,617
• Time in Patent Office: 2,113 Days
• Field of Search: 424/426, 427/248.1, 427/250, 106/1.05, 106/1.13, 106/1.14, 106/1.15, 106/1.16, 106/1.17, 106/1.18, 106/1.19, 106/1.21, 106/723, 106/733
• US Class Current: 424/426
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61B 2018/00119 with metal oxide nitride
• CPC Class Codes: A61L 17/145 Coating
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2300/63 Crystals
• CPC Class Codes: A61L 27/306 Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/106 Inorganic materials other than carbon
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C23C 14/0036 Reactive sputtering
• CPC Class Codes: C23C 14/025 Metallic sublayers
• CPC Class Codes: C23C 14/06 characterised by the coating material C23C14/0021 , C23C14/04 take precedence
• CPC Class Codes: C23C 14/0688 Cermets, e.g. mixtures of metal and one or more of carbides, nitrides, oxides or borides
• CPC Class Codes: C23C 14/086 of zinc, germanium, cadmium, indium, tin, thallium or bismuth
• CPC Class Codes: C23C 14/14 Metallic material, boron or silicon
• CPC Class Codes: C23C 14/16 : on metallic substrates or on substrates of boron or silicon
• CPC Class Codes: C23C 14/205 : by cathodic sputtering
• CPC Class Codes: C23C 14/225 : Oblique incidence of vaporised material on substrate
• CPC Class Codes: C23C 14/35 : by application of a magnetic field, e.g. magnetron sputtering C23C14/3457 takes precedence
• CPC Class Codes: C23C 14/588 : by mechanical treatment
• CPC Class Codes: H01H 2300/014 : Application surgical instrument
• CPC Class Codes: Y10S 977/899 : Electrolytic
• CPC Class Codes: Y10S 977/915 : Therapeutic or pharmaceutical composition

Abstract

Production of an anti-microbial effect in an alcohol or water based electrolyte is achieved by preparing silver materials that form complex ions other than Ag⁺, Ag²⁺, or Ag³⁺, and which produce an anti-microbial effect that is greater than that produced by an equivalent amount of silver as Ag⁺. Exemplary complex silver ions produced include Ag(CN)₂^-, AgCN(_aq)(ion pair), Ag(NH₃)₂⁺, AgCl₂^-, Ag(OH)₂^-, Ag₂ (OH)₃^-, Ag₃ (OH)₄^-, and Ag(S₂ O₃)₂^3-. The silver materials may be prepared as powders or as solutions or suspensions containing the complex silver ions. The silver materials might also be prepared as coatings, foils, powders, or fine grain or nanocrystalline powders, which are formed with atomic disorder to provide sustained release of the complex silver ions.

Claims

1. A method of producing an anti-microbial effect or in a an alcohol or water based electrolyte, comprising:

(a) preparing a silver material such that it forms complex silver ions other than Ag⁺, Ag²⁺ or Ag³⁺, in an amount so as to produce an anti-microbial effect in contact with an alcohol or a water-based electrolyte that is greater than that produced by an equivalent amount of silver as Ag⁺ ; and

(b) bringing the silver material into contact with the alcohol or electrolyte to be treated so as to cause the release of the complex silver ions.

2. The method as set forth in claim 1, wherein the silver material forms one or more of the complex silver ions Ag(CN)₂^-, AgCN(aq)(ion pair), Ag(NH₃)₂⁺, AgCl₂^-, Ag(OH)₂^-, Ag₂ (OH)₃^-, Ag₃ (OH)₄^- and Ag(S₂ O₃)₂^3- in contact with an alcohol or a water based electrolyte.

3. The method as set forth in claim 2, wherein the silver material is prepared as a powder, solution or suspension containing one or more of the complex silver ions.

4. The method as set forth in claim 1, wherein the silver material is prepared by creating atomic disorder in a silver metal under conditions which limit diffusion such that atomic disorder is retained in the material to provide sustained release of a complex silver ion into the alcohol or water based electrolyte at a concentration sufficient to provide a localized anti-microbial effect.

5. The method as set forth in claim 4, wherein the silver material forms one or more of the complex silver ions Ag(OH)₂^-, Ag₂ (OH)₃^-, and Ag₃ (OH)₄^-.

6. The method as set forth in claim 4, wherein the material is a powder or foil of silver metal and wherein the atomic disorder is formed by cold working of the powder or foil.

7. The method as set forth in claim 4, wherein the silver material is a fine grain or nanocrystalline powder.

8. The method as set forth in claim 4 or 5, wherein the silver material is formed as a coating on a substrate by vapour deposition under conditions which limit diffusion during deposition and which limit annealing or recrystallization following deposition.

9. The method as set forth in claim 8, wherein the coating is formed by vacuum evaporation, sputtering, magnetron sputtering or ion plating.

10. The method as set forth in claim 8, wherein the coating is formed by magnetron sputtering at conditions such that the ratio of the temperature of the surface being coated to the melting point of silver is less than about 0.5, and the working gas pressure is greater than about 10 mT.

11. The method as set forth in claim 9, wherein the silver material is a composite coating formed by co-, sequentially or reactively depositing the silver metal in a matrix with atoms or molecules of a different material such that atomic disorder is created in the matrix, said different material being selected from one or more of oxygen, nitrogen, hydrogen, boron, sulphur or halogen absorbed or trapped in the matrix from the atmosphere of the vapour deposition, or an oxide, nitride, carbide, boride, halide, sulphide, or hydride of silver or of an inert biocompatible metal selected from Ta, Ti, Nb, V, Hf, Zn, Mo, Si and Al.

12. The method as set forth in claim 10, wherein the different material is one or more of silver oxide and atoms or molecules containing oxygen trapped or absorbed from the atmosphere of the vapour deposition.

13. The method as set forth in claim 1, 2, 3 or 4, wherein the silver material is prepared as an anti-microbial coating on a medical device.

14. The method as set forth in claim 1, 2, 3 or 4, wherein the silver material is prepared as a powder for use in the preparation of a topical anti-microbial composition.

15. The method as set forth in claim 1, wherein the silver material forms one or more of the complex silver ions Ag(CN)₂^-, AgCN(aq)(ion pair), Ag(NH₃)₂⁺, Ag(OH)₂^-, Ag₂ (OH)₃^-, and Ag₃ (OH)₄^- in contact with the alcohol or electrolyte.

16. The method as set forth in claim 1, wherein the silver material forms one or more of the complex silver ions Ag(CN)₂^-, AgCN(aq)(ion pair), and Ag(NH₃)₂⁺, in contact with the alcohol or electrolyte.