Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos
First Claim
1. An antisense oligonucleotide consisting of a nucleic acid sequence selected from a group consisting of SEQ ID NO:
- 10, 11, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 27, 120, 121, 122, 123, 131, 132, 133, 134, 135, 136, 137 and 138 wherein said oligonucleotide inhibits the expression of c-Fos protein.
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Accused Products
Abstract
Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of Activating Protein 1 (AP-1) expression are provided. In accordance with various embodiments of the present invention, oligonucleotides are provided which are specifically hybridizable with c-fos or c-jun, the genes encoding c-Fos or c-Jun, respectively. In a preferred embodiment, a method of modulating the metastasis of malignant tumors via modulation of one or more of the AP-1 subunits is provided; this method can be effected using the oligonucleotides of the invention or any other agent which modulates AP-1 or AP-1-mediated transcription.
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Citations
44 Claims
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1. An antisense oligonucleotide consisting of a nucleic acid sequence selected from a group consisting of SEQ ID NO:
- 10, 11, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 27, 120, 121, 122, 123, 131, 132, 133, 134, 135, 136, 137 and 138 wherein said oligonucleotide inhibits the expression of c-Fos protein.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 41, 42)
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21. An antisense oligonucleotide consisting of a nucleic acid sequence selected from a group consisting of SEQ ID NO:
- 1, 3, 4, 5, 6, 7, 8, 9, 36 and 37, wherein said oligonucleotide inhibits the expression of c-Jun protein.
- View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 43, 44)
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39. An antisense oligonucleotide consisting of a nucleobase sequence that is 8 to 30 nucleotides in length is specifically hybridizable with at least a portion of the sequence
3'"'"'- ACGGGGAGTCGGGGCTGCCAGAGAGAAGT-5'"'"' (SEQ ID NO:
Specification