Platinum-containing compounds, methods for their preparation and applications thereof
First Claim
1. A detectable label compound, having the structure:
- ##STR35## wherein;
Pt is a platinum atom;
N is a detectable marker moiety;
A is a displaceable leaving group; and
X and Y are stabilizing substituents.
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Abstract
The invention provides platinum-based probe compounds having the structure: ##STR1## wherein: Pt is a platinum atom, PROBE is a probe biomolecule for associating to a target biomolecule, M is a detectable marker moiety, and X and Y are stabilizing substituents. Also provided are platinum-based labeling compounds having the structure: ##STR2## wherein: Pt is a platinum atom, M is a detectable marker moiety, A is a displaceable leaving group, and X and Y are stabilizing substituents. The invention further provides platinum-based linker compounds having the structure: ##STR3## wherein: Pt is a platinum atom, A and B are the same or different reactive moieties, and X and Y are stabilizing substituents. Other PtII and PtIV compounds are also provided. Moreover, the invention provides methods for the preparation and use of these compounds, as well as diagnostic kits which contain the compounds.
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15 Claims
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1. A detectable label compound, having the structure:
- ##STR35## wherein;
Pt is a platinum atom;N is a detectable marker moiety; A is a displaceable leaving group; and X and Y are stabilizing substituents. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- ##STR35## wherein;
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12. A platinum-based binding substance, having the structure:
- ##STR36## wherein;
Pt is a platinum atom;PROBE is a probe biomolecule for associating to a target biomolecule; SUBSTRATE is a substantially solid material; and X and Y are stabilizing substituents. - View Dependent Claims (13, 14, 15)
- ##STR36## wherein;
Specification