Phosphonic diester derivatives
First Claim
1. A phosphonic diester derivative represented by the following formula (1):
- ##STR60## wherein R1 represents a cycloalkyl group;
a phenyl group which may have 1 to 3 substituents selected from the group consisting of a lower alkoxy group, a lower alkyl group, a halogen atom, a halogen-substituted lower alkyl group, a lower alkanoyl group, a nitro group, a benzoyl group, a cyano group, an N-lower alkylcarbamoyl group, an N-phenyl-lower alkylcarbamoyl group, an N-(halogen-substituted phenyl)carbamoyl group and an N,N-di-lower alkylcarbamoyl group;
a 1,3,4-thiadiazol-2-yl group having a halogen-substituted lower alkyl group as a substituent;
a thiazolyl group;
a pyridyl group which may be substituted by a halogen atom;
a benzothiazol-2-yl group having 1 to 2 lower alkoxy groups on the phenyl ring;
or a 4,5-dihydrothieno[3,2-e]benzothiazol-2-yl group;
R2 represents a hydrogen atom or a phenyl lower alkyl group;
R3 and R4 each represents a lower alkyl group; and
A represents a heterocyclic ring selected from the group consisting of a pyrazine ring, a thiophene ring and a phenyl-substituted thiazole ring.
1 Assignment
0 Petitions
Accused Products
Abstract
A phosphonic diester derivative represented by the following formula (1): ##STR1## wherein R1 represents a cycloalkyl group; a phenyl group which may have 1 to 3 substituents selected from the group consisting of a lower alkoxy group, a lower alkyl group, a halogen atom, a halogen-substituted lower alkyl group, a lower alkanoyl group, a nitro group, a benzoyl group, a cyano group, an N-lower alkylcarbamoyl group, an N-phenyl-lower alkylcarbamoyl group, an N-(halogen-substituted phenyl)carbamoyl group and an N,N-di-lower alkylcarbamoyl group; a 1,3,4-thiadiazol-2-yl group having a halogen-substituted lower alkyl group as a substituent; a thiazolyl group; a pyridyl group which may be substituted by a halogen atom; a benzothiazol-2-yl group having 1 to 2 lower alkoxy groups on the phenyl ring; or a 4,5-dihydrothieno[3,2-e]benzothiazol-2-yl group; R2 represents a hydrogen atom or a phenyl lower alkyl group; R3 and R4 each represents a lower alkyl group; and A represents a heterocyclic ring selected from the group consisting of a pyrazine ring, a thiophene ring and a phenyl-substituted thiazole ring; the derivative being of value as an agent for treating and preventing hyperlipidemia, diabetes and cataract, or as an antitumor agent.
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Citations
9 Claims
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1. A phosphonic diester derivative represented by the following formula (1):
- ##STR60## wherein R1 represents a cycloalkyl group;
a phenyl group which may have 1 to 3 substituents selected from the group consisting of a lower alkoxy group, a lower alkyl group, a halogen atom, a halogen-substituted lower alkyl group, a lower alkanoyl group, a nitro group, a benzoyl group, a cyano group, an N-lower alkylcarbamoyl group, an N-phenyl-lower alkylcarbamoyl group, an N-(halogen-substituted phenyl)carbamoyl group and an N,N-di-lower alkylcarbamoyl group;
a 1,3,4-thiadiazol-2-yl group having a halogen-substituted lower alkyl group as a substituent;
a thiazolyl group;
a pyridyl group which may be substituted by a halogen atom;
a benzothiazol-2-yl group having 1 to 2 lower alkoxy groups on the phenyl ring;
or a 4,5-dihydrothieno[3,2-e]benzothiazol-2-yl group;
R2 represents a hydrogen atom or a phenyl lower alkyl group;
R3 and R4 each represents a lower alkyl group; and
A represents a heterocyclic ring selected from the group consisting of a pyrazine ring, a thiophene ring and a phenyl-substituted thiazole ring. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- ##STR60## wherein R1 represents a cycloalkyl group;
Specification