Treatment of neurodegenerative conditions with nimesulide
First Claim
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1. A method of preventing non-inflammatory neuronal cell death in a patient suffering from a neurodegenerative condition comprising administering, to the subject, an effective amount of nimcsulide.
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Abstract
The present invention relates to the use of nimesulide and structurally related compounds in the prevention and/or treatment of neurodegenerative conditions. It is based, at least in part, on the discovery that nimesulide exhibits a neuroprotective effect against β-amyloid induced cell death. Without being bound to any particular theory, it appears that nimesulide inhibits a non-inflammatory mechanism of neurodegeneration.
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9 Claims
- 1. A method of preventing non-inflammatory neuronal cell death in a patient suffering from a neurodegenerative condition comprising administering, to the subject, an effective amount of nimcsulide.
- 3. A method of preventing neuronal cell death in a patient suffering from amyotrophic lateral sclerosis comprising administering, to the subject, an effective amount of nimesulide.
- 4. A method of preventing ncuronal cell death in a patient suffering from a neurodegenerative condition is caused by chronic epilepsy comprising administering, to the subject, an effective amount of nimesulide.
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9. A method of treating Alzheimer'"'"'s disease comprising administering, to a subject in need of such treatment, a neuroprotective amount of nimesulide which results in exposure of the affected neurons to a local concentration of nimesulide of one micromolar or a lower concentration that inhibits neuronal cell death by at least 20 percent.
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