Peracylated proteins and synthetic polypeptides and process for making the same
First Claim
1. A melt-processable soy protein composition made by the process comprising the steps of:
- dispersing a soy protein in an essentially non-aqueous medium; and
peracylating the soy protein with at least two acyl groups per protein chain by reacting the protein with a cyclic anhydride having a carbon chain substituent comprising at least eight carbon atoms per chain and selected from the group consisting of alkyl and alkenyl groups in the presence of an acid catalyst.
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Accused Products
Abstract
A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or polypeptide with a cyclic anhydride having a carbon chain substituent selected from the group consisting of alkyl and alkenyl groups. Most preferably, the cyclic anhydride is succinic anhydride, although glutaric anhydride may also be employed. Preferably, the step of peracylating the protein or polypeptide is performed in the presence of an acid catalyst, most preferably ρ-toluene sulfonic acid. The resultant modified protein or polypeptide may be employed in numerous applications including drug delivery, absorbable sutures, and thermoplastic films and molded articles.
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Citations
16 Claims
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1. A melt-processable soy protein composition made by the process comprising the steps of:
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dispersing a soy protein in an essentially non-aqueous medium; and peracylating the soy protein with at least two acyl groups per protein chain by reacting the protein with a cyclic anhydride having a carbon chain substituent comprising at least eight carbon atoms per chain and selected from the group consisting of alkyl and alkenyl groups in the presence of an acid catalyst. - View Dependent Claims (2, 3, 4)
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5. A melt-processable, synthetic polypeptide composition made by the process comprising the steps of:
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dispersing a synthetic polypeptide in an essentially non-aqueous medium; and peracylating the synthetic polypeptide with at least two acyl groups per synthetic polypeptide chain by reacting the synthetic polypeptide with a cyclic anhydride having a carbon chain substituent comprising at least eight carbon atoms per chain and selected from the group consisting of alkyl and alkenyl groups in the presence of an acid catalyst. - View Dependent Claims (6, 7)
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8. A method for modifying a soy protein or synthetic polypeptide comprising the steps of:
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dispersing a soy protein or synthetic polypeptide in an essentially non-aqueous medium; and peracylating the soy protein or synthetic polypeptide with at least two acyl groups per soy protein or synthetic polypeptide chain by reacting the soy protein or synthetic polypeptide with a cyclic anhydride having a carbon chain substituent comprising at least eight carbon atoms per chain and selected from the group consisting of alkyl and alkenyl groups in the presence of an acid catalyst. - View Dependent Claims (9, 10, 11)
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12. A modified, soy protein-based article made by the process comprising the steps of:
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forming a soy protein into an article; subjecting the article to an essentially non-aqueous medium; surface peracylating the article with a cyclic anhydride having a carbon chain substituent comprising at least eight carbon atoms per chain and selected from the group consisting of alkyl and alkenyl groups in the presence of an acid catalyst. - View Dependent Claims (13, 14, 15, 16)
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Specification