Medical diagnostic apparatus using a Fresnel reflector

• US 5,986,754 A
• Filed: 12/08/1997
• Issued: 11/16/1999
• Est. Priority Date: 12/08/1997
• Status: Expired due to Term

• Current Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Original Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Inventors: Harding, Ian
• Primary Examiner(s): Rosenberger, Richard A.
• Application Number:
  US08/986,560
• Time in Patent Office: 708 Days
• Field of Search: 356/246, 356/436, 356/444, 356/39
• US Class Current: 356/246
• CPC Class Codes: G01N 2021/0346 Capillary cells; Microcells
• CPC Class Codes: G01N 21/05 Flow-through cuvettes G01N21/09 takes precedence; handling fluid samples G01N1/10

Abstract

A device for use in a medical diagnostic apparatus includes an area for containing a sample of biological fluid as it undergoes a reaction that causes a detectable change in the sample'"'"'s optical properties. The reaction area is sandwiched between a transparent front layer and a Fresnel reflector layer. The area is illuminated through the front layer, and the light is reflected from the reflector layer to a detector. The detector monitors the light incident on it and calculates, from the change during the course of the reaction, an analyte concentration or property of the fluid sample. The reaction area is optionally heated.

Claims

1. For use in a medical diagnostic apparatus that comprises a light source to illuminate a sample of a biological fluid and a detector to detect light that has passed through the sample, a device that comprises

(a) a reaction area for containing at least a portion of the sample, sandwiched between

(b) a substantially transparent first layer, and

(c) a second layer, comprising a metallized thermoplastic sheet having means for making an electrical connection to the metallized sheet and including a Fresnel reflector, for providing specular reflection of light that has passed through the first layer and the reaction area and directing the light toward the detector.

2. The device of claim 1 in which the biological fluid is whole blood or blood plasma.

3. The device of claim 2 in which the reaction area comprises a reagent that reacts with the blood or plasma to change an optical property thereof in a way that can be quantitatively related to a blood clotting characteristic.

4. The device of claim 1 in which the Fresnel reflector comprises a surface of the second layer that is reflective and that adjoins the reaction area.

5. The device of claim 4 in which the reflective surface is grooved and is spaced apart from an adjoining surface of the first layer a distance that is small enough to maintain a capillary flow of sample into the reaction area when the sample is introduced between the adjoining surfaces.

6. The device of claim 1 in which the Fresnel reflector is separated from the reaction area by a transparent section of the second layer.

7. The device of claim 1 in which the first layer comprises a thermoplastic sheet.