Method of making medical electrical lead

• US 5,987,746 A
• Filed: 02/21/1996
• Issued: 11/23/1999
• Est. Priority Date: 02/21/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Williams, Terrell M.
• Primary Examiner(s): Arbes, Carl J.
• Application Number:
  US08/604,591
• Time in Patent Office: 1,371 Days
• Field of Search: 29/825, 29/876, 607/120
• US Class Current: 29/876
• CPC Class Codes: A61N 1/0568 with drug delivery
• CPC Class Codes: Y10T 29/49117 Conductor or circuit manufacturing
• CPC Class Codes: Y10T 29/49208 by assembling plural parts

Abstract

A medical electrical lead having a drug which is no more than sparingly soluble in water applied to the electrode surface. In the preferred embodiment the lead of the present invention possesses an electrode treated with a very slightly soluble in water steroid, such as beclomethasone dipropionate anhydrous. Preferably the steroid is applied to the surface of the electrode which contacts tissue when implanted. A method of manufacturing such a lead is also disclosed. Through such a design, a high impedance, low threshold lead which is simple and easy to manufacture is disclosed.

Claims

1. A method of manufacturing a medical electrical lead comprising the steps of:

assembling a lead;

mixing a very slightly soluble in water steroid with an organic solvent to form a solution;

applying the solution to the lead; and

drying the solution on the lead to drive off the organic solvent.

2. The method of manufacturing medical electrical lead according to claim 1 wherein the step of mixing a very slightly soluble in water steroid with an organic solvent to form a solution comprises the steps of dissolving beclomethasone dipropionate anhydrous in acetone.

3. The method of manufacturing a medical electrical lead according to claim 2 wherein the step of dissolving beclomethasone dipropionate anhydrous into acetone comprises forming a saturated solution of beclomethasone dipropionate anhydrous in acetone.

4. The method of manufacturing medical electrical lead according to claim 1 wherein the step of mixing a very slightly soluble in water steroid with an organic solvent to form a solution comprises mixing a very slightly soluble in water steroid with an organic solvent to form a saturated solution.

5. The method of manufacturing medical electrical lead according to claim 1 wherein the step of applying the solution to the lead comprises applying a saturated solution of beclomethasone dipropionate anhydrous in acetone.

6. A method of manufacturing a medical electrical lead comprising the steps of:

assembling a lead, the lead having an electrode;

forming a saturated solution of a steroid which is at least very slightly soluble in water and a solvent;

applying the saturated solution to the electrode; and

drying the saturated solution on the electrode to drive off the organic solvent but not the steroid from the electrode.

7. The method of manufacturing medical electrical lead according to claim 6 wherein the step of applying the saturated solution to the electrode comprises applying the saturated solution to an exterior surface of the electrode.

8. The method of manufacturing medical electrical lead according to claim 6 wherein the step of forming a saturated solution of a steroid which is at least very slightly soluble in water and a solvent comprises the steps of dissolving beclomethasone dipropionate anhydrous into acetone.

9. The method of manufacturing medical electrical lead according to claim 8 wherein the step of applying the saturated solution to the electrode comprises applying a saturated solution of beclomethasone dipropionate anhydrous in acetone.

10. The method of manufacturing medical electrical lead according to claim 6 wherein the step of mixing a very slightly soluble in water steroid with an organic solvent to form a solution comprises mixing a very slightly soluble in water steroid with an organic solvent to form a saturated solution.

11. A method of manufacturing a medical electrical lead comprising the steps of:

assembling a lead, the lead having an electrode;

forming a saturated solution of a drug which is at least very slightly soluble in water and a solvent;

depositing on the surface of the electrode the saturated solution to the electrode; and

driving off the solvent from the saturated solution deposited on the electrode such that the drug remains on the surface of the electrode.

12. The method of manufacturing medical electrical lead according to claim 11 wherein the step of driving off the solvent from the saturated solution deposited on the electrode such that the drug remains on the surface of the electrode comprises drying the saturated solution.

13. The method of manufacturing medical electrical lead according to claim 11 wherein the step of forming a saturated solution of a drug which is at least very slightly soluble in water and a solvent comprises forming a saturated solution of a steroid which is at least very slightly soluble in water and a solvent.

14. The method of manufacturing medical electrical lead according to claim 11 wherein the step of forming a saturated solution of a steroid which is at least very slightly soluble in water and a solvent comprises the steps of dissolving beclomethasone dipropionate anhydrous into acetone.

15. The method of manufacturing medical electrical lead according to claim 14 wherein the step of applying the saturated solution to the electrode comprises applying a saturated solution of beclomethasone dipropionate anhydrous in acetone.

16. The method of manufacturing medical electrical lead according to claim 11 wherein the step of mixing a very slightly soluble in water drug with an organic solvent to form a solution comprises mixing a very slightly soluble in water steroid with an organic solvent to form a saturated solution.