Probe for heating body tissue

• US 5,989,246 A
• Filed: 02/09/1995
• Issued: 11/23/1999
• Est. Priority Date: 06/29/1992
• Status: Expired due to Fees

• Current Assignee: Hans-Joachim Schwarzmaier, Raimund Kaufmann
• Original Assignee: Hans-Joachim Schwarzmaier, Raimund Kaufmann
• Inventors: Schwarzmaier, Hans-Joachim, Kaufmann, Raimund
• Primary Examiner(s): Nasser, Robert L.
• Application Number:
  US08/362,430
• Time in Patent Office: 1,748 Days
• Field of Search: 606/7, 606/9, 606/13-18, 606/27-31, 607/88-94, 607/154, 62/434
• US Class Current: 606/15
• CPC Class Codes: A61B 2018/2261 with scattering, diffusion or dispersion of light
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/067 using laser light

Abstract

The invention concerns a probe for heating body tissue by means of high-intensity laser light, the probe having an optical fibre coupled to a laser source and a diffusor element located in the light-exit zone which is inserted into the body tissue. The diffusor element is made of a material which is highly transparent to the laser light but which contains highly reflective particles embedded in it. The probe is connected to a coolant circuit to cool the light-exit zone.

Claims

1. A probe for heating body tissue by high-intensity laser light from a laser light source, said probe comprising:

a light guide for coupling to the laser light source and having an exit portion to be introduced into the body tissue;

a diffuser element on the light guide made of a base material which is highly transparent to laser light;

particles of material highly reflective to laser light embedded in the base material;

a tubular sleeve surrounding and spaced from the light guide at a predetermined distance;

the tubular sleeve having a cap at an end thereof being made of a material that is transparent to laser light and has good heat conductivity in the area of the diffuser element to transmit heat by conduction and by radiation to the body tissue;

the diffuser element being spaced from the cap and surrounded by coolant with coolant between the cap and the diffuser element;

the cap allowing isotropic scattering of laser light from the diffuser element; and

means including a closed coolant passageway in the tubular sleeve having a channel for flowing coolant through the tubular sleeve toward the body tissue and surrounding the diffuser element to remove a substantial portion of the heat transmitted to the body tissue by heat conduction and from the body tissue, while the laser light source is being operated to produce heat radiation for tumor therapy.

2. A probe according to claim 1, wherein the particles of highly reflective material are selected from the group consisting of barium sulphate, magnesium oxide and aluminum powder.

3. A probe according to claim 1 wherein the diffuser element material is selected from the group comprising glass, glass-like plastics, transparent adhesives and methyl acrylates.

4. A probe according to claim 1 wherein the particles of highly reflective material are homogeneously distributed in the transparent material.

5. A probe according to claim 1 wherein the particles of highly reflective material are distributed non-homogeneously in said transparent material dependent on a desired radiation characteristic.

6. A probe according to claim 1 wherein said diffuser element is shaped to produce an approximately spherical heat radiation characteristic.

7. A probe according to claim 1 wherein said diffuser element is shaped to produce an approximately cylindrical heat radiation characteristic.

8. A probe according to claim 1 wherein said light guide is hollow and has coolant flowing therein, said light guide and said outer sleeve being spaced to form the passageway for the coolant to flow.

9. A probe according to claim 1 wherein the tubular sleeve has a free probe end, a membrane divides the passageway in the tubular sleeve into at least two channels extending in parallel to the axis, and wherein said channels communicate in the area of the free probe end.

12. A probe according to claim 1 wherein the outer sleeve surrounding the light guide is flexible.

13. A probe according to claim 1 wherein the coolant has a sufficient viscosity to flow even at temperatures below 0°

C.

14. A probe according to claim 13 further comprising said coolant which is a mixture of a 0.9% sodium chloride solution and alcohol or methanol.

15. A probe according to claim 1, wherein the materials forming at least the cap of the probe are nuclear magnetic resonance-compatible.

16. A probe according to claim 1 wherein a tip on the probe is adapted for puncturing solid tissue at its distal end.

17. A probe according to claim 1 wherein the cap of the tubular sleeve is made of diamond or quartz glass.

10. A probe for heating body tissue by high-intensity laser light from a laser light source, said probe comprising:

a light guide for coupling to the laser light source and having an exit portion to be introduced into the body tissue;

a diffuser element on the light guide made of a base material which is highly transparent to laser light;

particles of material highly reflective to laser light embedded in the base material;

a tubular sleeve surrounding and spaced from the light guide at a predetermined distance;

the tubular sleeve being made of a material that is transparent to laser light and has good heat conductivity in the area of the diffuser element to transmit heat by conduction and by radiation to the body tissue; and

means including a closed coolant passageway in the tubular sleeve having a channel for flowing coolant through the tubular sleeve toward the body tissue to remove a substantial portion of the heat transmitted to the body tissue by heat conduction and from the body tissue while the laser light source is being operated to produce heat radiation for tumor therapy;

the tubular sleeve having a free probe end, an inner coaxial sleeve having a radially inner and outer sleeve, the radially inner sleeve surrounding the light guide and forming a first channel portion between said inner sleeve and said light guide and a radially inner one of said sleeves, and a second channel portion being formed between the two sleeves;

the two sleeves being transparent and have good heat conductivity at least in the area of the diffuser element, and wherein said two channel portions communicate in the area of the free probe end.

11. A probe according to claim 10 wherein in that the tubular sleeves surrounding the light guide are rigid tubes.

18. A method of heating body tissue with a probe receiving high-intensity laser light from a light source, said method comprising the steps of:

inserting the probe into the tissue;

generating the laser light and transmitting the laser light through a light guide to a diffuser element at an exit end of the probe, the probe at the diffuser element being less than about 2.5 mm in diameter;

applying at least 30 watts of power to the light guide probe;

scattering the laser light in a desired solid angle from the diffuser element to the tissue;

surrounding the diffuser element with coolant to cool the exit end of the probe;

cooling the exit end of the probe and the tissue in contact therewith with a coolant that removes more than one-half of laser energy thereby removing a large portion of the heat that would be transmitted by conduction to the tissue in the immediate vicinity of the diffuser element; and

heating the tissue primarily by radiation to a temperature increase of at least 7°

C. for tumor therapy.

19. A method in accordance with claim 18 including a cooling system and removing about 80% or more of the laser energy.

20. A method in accordance with claim 18 including the step of cooling the temperature of the tissue close to the diffuser element down to about 0°

C.

21. A method in accordance with claim 18 including the steps of providing power in the range of 30 watts to 100 watts, and removing about 80% to 90% of the power by the coolant.