Method, instruments and kit for autologous transplantation

• US 5,989,269 A
• Filed: 05/15/1997
• Issued: 11/23/1999
• Est. Priority Date: 08/30/1996
• Status: Expired due to Term

• Current Assignee: Vericel Corporation
• Original Assignee: VTS Holdings LLC
• Inventors: Idouraine, Ahmed, Lundsgaard, Charlotte, Vibe-Hansen, Henrik, Osther, Kurt B.
• Primary Examiner(s): Buiz, Michael
• Assistant Examiner(s): PHAM, THUY D
• Application Number:
  US08/857,090
• Time in Patent Office: 922 Days
• Field of Search: 606/214, 606/151, 602/1, 602/41, 602/48
• US Class Current: 606/151
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61F 2/2846 Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/38 for elbows or knees
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/30016 differing in hardness, e.g. Vickers, Shore, Brinell
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30535 Special structural features of bone or joint prostheses not otherwise provided for
• CPC Class Codes: A61F 2002/30761 Support means for artificial cartilage, e.g. cartilage defect covering membranes
• CPC Class Codes: A61F 2002/30762 Means for culturing cartilage
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2250/0019 differing in hardness, e.g. Vickers, Shore, Brinell
• CPC Class Codes: A61F 2250/0058 Additional features; Implant or prostheses properties not otherwise provided for
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus

Abstract

Method for the effective transplantation of chondrocytes/cartilage to an articular joint surface defect is taught, as well as a description of certain instruments and kit for practicing the invention.

Claims

1. A method for the effective treatment of articulating joint surface cartilage by the transplantation of chondrocytes in a suitable matrix, to a surface to be treated at a graft site with a hemostatic barrier and a covering-patch comprising:

first sculpting the graft site such that the walls of the graft site are non-linear and undulating, placing a hemostatic barrier proximal to the surface to be treated within the sculpted graft site, placing chondrocytes in a suitable matrix within the graft site upon the hemostatic barrier, covering the surface to be treated with a covering-patch.

2. The method of claim 1 wherein the covering-patch is partially attached prior to the placing of chondrocytes in a suitable matrix, within the graft site upon the hemostatic barrier.

3. The method of claim 1 wherein the hemostatic barrier is a resorbable semi-permeable material which inhibits or prohibits vascular infiltration through the barrier.

4. The method of claim 1 wherein the covering-patch is a cell-free semi-permeable collagen matrix.

5. The method of claim 3 wherein the hemostatic barrier contains collagen.

6. A kit for the practice of the method of claim 1 comprising a hemostatic barrier treated to inhibit resorption, a covering-patch treated to inhibit resorption, an organic glue, and optionally a surgical instrument for sculpting the walls of the graft site, and optionally a matrix material suitable for supporting chondrocytes placed within the graft site.