Active blood filter and method for active blood filtration

• US 5,989,438 A
• Filed: 12/12/1997
• Issued: 11/23/1999
• Est. Priority Date: 12/12/1997
• Status: Expired due to Fees

• Current Assignee: Jostra Bentley, Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Fumiyama, Hideo
• Primary Examiner(s): Walker, W. L.
• Assistant Examiner(s): Ward, Richard W.
• Application Number:
  US08/989,316
• Time in Patent Office: 711 Days
• Field of Search: 210/85, 210/97, 210/418, 210/420, 210/739, 210/745, 210/746, 210/767, 604/65, 604/67, 604/4, 604/5, 604/122, 251/7, 237/599
• US Class Current: 210/745
• CPC Class Codes: A61M 1/36 Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
• CPC Class Codes: A61M 1/3626 Gas bubble detectors
• CPC Class Codes: A61M 2206/16 Rotating swirling helical flow, e.g. by tangential inflows
• CPC Class Codes: B07C 5/342 according to optical properties, e.g. colour according to radiation transmittivity B07C5/3416
• CPC Class Codes: B07C 5/36 Sorting apparatus characterised by the means used for distribution sorting according to destination B07C3/003, B07C3/02
• CPC Class Codes: G01N 33/491 by separating the blood components G01N15/05 takes precedence

Abstract

A blood filter is disclosed which actively removes unwanted particles from the blood without using passive elements such as a cartridge. The blood filter includes a housing having a blood inlet area for receiving blood to be filtered, a blood outlet area for providing filtered blood to a patient, and a blood return area for returning blood having unwanted particles to a reservoir. A plurality of independent blood paths extend from the inlet area to the outlet area of the housing for separate flows of blood therethrough. An array of detectors is placed adjacent the exterior of each blood path for detecting unwanted particles in the blood flowing therethrough. An array of valves is placed in operable relationship with the blood paths to close selected ones of the blood paths when unwanted particles are detected. Blood return conduits open to divert the particle-containing blood to a reservoir. Several arrays of detectors and valve combinations may be provided for redundancy. A feedback and control circuit monitors the number of closed blood paths and sends control or alarm signals when the outlet blood flow reduces below a predetermined minimum. A spiral-shaped inlet manifold distributes the incoming blood into different regions corresponding to mass to help improve the efficiency of the filter.

Claims

1. A blood filter for removing unwanted particles from blood, comprising:

a housing having a blood inlet area for receiving blood to be filtered, a blood outlet area, and a blood return area for returning blood having unwanted particles to a reservoir;

a plurality of separate blood paths extending from the inlet area to the outlet area of the housing for flowing the blood therethrough, wherein each of the blood paths includes;

a detector adjacent to the blood path for detecting unwanted particles in the blood flowing through the blood path;

a valve in operable relationship with the blood path for closing the blood path when an unwanted particle is detected by the detectors; and

a circuit for limiting the number of the valves that close to ensure an adequate blood flow from the intlet to the outlet of the filter.

2. A blood filter as defined in claim 1, further comprising:

a plurality of return conduits, one return conduit connecting to each of the blood paths and extending to the blood return area of the housing to allow blood having unwanted particles to flow to the reservoir, wherein each of the return conduits includes;

a detector adjacent to the blood return conduit for monitoring the unwanted particles in the blood flowing through the blood return conduits; and

a valve in operable relationship with the blood return conduit for opening the blood return conduit and for enabling blood having an unwanted particle to flow to the reservoir.

3. A blood filter as defined in claim 1, wherein the inlet area of the housing has a spiral structure to impart momentum to blood entering the housing so that the blood is distributed to the plurality of blood paths based on the momentum of the particles.

4. A blood filter as defined in claim 1, wherein an average number of blood paths closed at any one time is predetermined, and the inlet cross-sectional area of the housing is substantially the same as a sum of the cross-sectional areas of all of the plurality of blood paths less the cross-sectional areas of the predetermined average number of blood paths closed at the same time by the valves.

5. A blood filter as defined in claim 1, further comprising:

an amplifier for amplifying a detection signal generated by each of the detectors and driving a corresponding one of the valves; and

means for detecting a number of detection signals from the detectors and prohibiting further closing of the blood paths by the valves when the number of the detection signals reaches a predetermined value.

6. A blood filter as defined in claim 1, wherein each of the blood paths is a tube made flexible enough to be physically squeezed shut to substantially prohibit blood from flowing when an external clamping force is applied thereto.

7. A blood filter as defined in claim 1, wherein each of the detectors is a combined LED and a photo diode for sensing light power changes through the blood.

8. A blood filter as defined in claim 1, wherein each of the detectors is an ultrasonic sensor for sensing acoustic changes in the blood.

9. A blood filter as defined in claim 1, wherein each of the detectors is an impedance sensor for sensing impedance changes in the blood.

10. A blood filter as defined in claim 1, wherein each of the valves is a mechanical clamp driven by an electric signal.

11. A blood filter as defined in claim 1, wherein each of the valves is an piezoelectric element driven by an electric signal.

12. The blood filter of claim 1 wherein the number of separate blood paths is 11.

13. A blood filter for removing unwanted particles from blood, comprising

a housing having a blood inlet area for receiving blood to be filtered, a blood outlet area, and a blood return area for returning blood having unwanted particles to a reservoir;

a plurality of blood paths extending in a downstream direction from the inlet area to the outlet area of the housing and adapted to flow blood therethrough;

a first array of detectors attached to an upstream portion of the blood paths for detecting unwanted particles in the blood flowing trough the blood paths;

a first array of valves attached to the blood paths downstream from the first array of detectors for closing selected ones of the blood paths when the unwanted particles are detected by the first array of detectors;

a second array of detectors attached to the blood paths downstream from the first array of valves for detecting unwanted particles in the blood flowing through the blood paths; and

a second array of valves attached to the blood paths downstream from the second array of detector for closing selected ones of the blood paths when the unwanted particles are detected by the second array of detectors; and

a third array of detectors attached to the blood paths downstream from the second array of valves for detection unwanted particles in the blood flowing through the blood paths.

14. A blood filter as defined in claim 13, further comprising:

a first plurality of return conduits connected to the blood paths between the first array of detectors and first array of valves and extending to the blood return area of the housing for flowing blood having unwanted particles to the reservoir;

a fourth array of detectors adjacent to the first plurality of return conduits for monitoring the unwanted particles in the blood flowing therethrough;

a third array of valves in operable relationship with the first plurality of return conduits for opening selected ones of the first plurality of return conduits;

a second plurality of return conduits connected the blood paths between the second array of detectors and second array of valves and extending to the blood return area of the housing for flowing blood enable blood having unwanted particles to flow to the reservoir having unwanted particles to the reservoir;

a fifth array of detectors adjacent to the second plurality of return conduits for monitoring the unwanted particles in the blood flowing therethrough; and

a fourth array of valves in operable relationship with the second plurality of return conduits for opening selected ones of the second plurality of return blood to enable blood having unwanted particles to flow to the reservoir.

15. A blood filter as defined in claim 13, wherein the inlet area of the housing has a spiral structure to impart momentum to blood entering the housing so that the blood is distributed to the plurality of blood paths based on the momentum of the particles.

16. A blood filter as defined in claim 13, wherein an average number of blood paths closed at any one time is predetermined, and the inlet cross-sectional area of the housing is substantially the same as a sum of the cross-sectional areas of all of the plurality of blood paths less the cross-sectional areas of the predetermined average number of blood paths closed at the same time by the valves.

17. A blood filter as defined in claim 13, further comprising a third array of detectors attached to the blood paths downstream from the second array of valves for detecting unwanted particles in the blood flowing through the blood paths.

18. A method or removing unwanted particles from blood, comprising the steps of:

supplying blood to an inlet of a blood filter having a blood outlet and a blood return;

concurrently flowing the blood through a plurality of separate blood paths extending from the inlet to the outlet of the blood filter;

detecting unwanted particles in the blood flowing through the blood paths and generating signals upon detection of particles;

closing selected ones of the blood paths based on the signals and returning the blood to a reservoir through the blood return; and

limiting the number of the closed blood paths to ensure an adequate blood flow from the inlet to the outlet of the filter.

19. The method of claim 18 wherein the limiting step includes monitoring the number of th closed blood paths and preventing further closure of additional blood paths.

20. A blood filter for removing unwanted particles from blood, comprising:

a housing having a blood inlet are for receiving blood to be filtered, a blood outlet area, and a blood return area for returning blood having unwanted particles to a reservoir;

a plurality of separate blood paths extending from the inlet area to the outlet area of the housing for flowing the blood therethrough, wherein each of the blood paths includes;

a detector adjacent to the blood path for detecting unwanted particles in the blood flowing through the blood path;

a valve in operable relationship with the blood path for closing the blood path when an unwanted particle is detected by the detector;

wherein the inlet area of the housing has a spiral structure to impart momentum to blood entering the housing so that the blood is distributed the plurality of blood paths based on the momentum of the particles.