Cosmetic/dermatological skin care compositions comprising S-DHEA

• US 5,989,568 A
• Filed: 01/26/1996
• Issued: 11/23/1999
• Est. Priority Date: 01/26/1995
• Status: Expired due to Fees

• Current Assignee: L'Oreal SA
• Original Assignee: L'Oreal SA
• Inventors: Breton, Lionel, De Lacharriere, Olivier
• Primary Examiner(s): VENKAT, JYOTHSNA A
• Application Number:
  US08/592,175
• Time in Patent Office: 1,397 Days
• Field of Search: 424/401, 424/450, 424/489, 514/844, 514/937, 514/944
• US Class Current: 424/401
• CPC Class Codes: A61K 8/63 Steroids; Derivatives thereof
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Dehydro-epi-androsterone sulfate, topically applied, is well suited for therapeutically treating human skin wrinkles and fine lines and/or for combating cutaneous and/or subcutaneous slackening and/or for reviving the radiance of the skin.

Claims

1. A method for the therapeutic treatment of a condition selected from the group consisting of wrinkles, fine lines, cutaneous and subcutaneous slackening, comprising topically applicable cosmetic/dermatological composition comprising a therapeutically effective amount of dehydro-epi-androsterone sulfate ("S-DHEA") contained in a cosmetically/dermatologically acceptable vehicle, carrier or diluent therefor.

2. The method of claim 1, wherein said topically applied composition further comprises at least one moiety selected from the group consisting of hydrophilic and lipophilic gelling agents, hydrophilic and lipophilic bioactive agents, preservatives, antioxidants, solvents, fragrances, fillers, sunscreens, bactericides, odor absorbers, dyestuffs, colorants, and combinations thereof.

3. The method as defined by claim 1, wherein said topically applied cosmetic/dermatological composition further comprises at least one moiety selected from the group consisting retinoids, α

-hydroxy acids, β

-hydroxy acids, α

-keto acids, β

-keto acids, benzoyl peroxide, vitamins, anti-free radical agents, and combination thereof.

4. The method as defined by claim 1, wherein the topically applied cosmetic/dermatological composition further comprises at least one hormone selected from the group consisting of progesterone, testosterone, anhydrous estradiol, broparoestrol, estrone, pregnenolone acetate, pregnenolone, 17-beta-hydroxyprogesterone, testosterone propionate, androstenedione, an androstanediol, and combinations thereof.

5. The method as defined by claim 1, wherein the topically applied cosmetic/dermatological composition comprises an amount ranging from about 0.00001% to 5% by weight of S-DHEA.

6. The method as defined by claim 5, wherein the topically applied cosmetic/dermatological composition comprises from an amount ranging from about 0.0001% to 1% by weight of S-DHEA.

7. The method as defined by claim 6, wherein the topically applied cosmetic/dermatological composition comprises an amount ranging from about 0.001% to 0.5% by weight of S-DHEA.

8. The method as defined by claim 1, wherein the topically applied cosmetic/dermatological composition comprises a formulation selected from the group consisting of aqueous, aqueous/alcoholic, oily solution dispersions, gels, emulsions, creams, lotions, microemulsions, microcapsules, microparticles, and vesicle dispersions.