Diagnostic compositions and devices utilizing same
First Claim
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1. A dry chemistry reagent matrix composition comprising a matrix material and a reagent composition comprising 3-methyl-6(M sulfonate)-benzothiazolinone-(2)-hydrazone (MBTH-S) where M is a positive ion providing a stable sulfonate salt;
- N-ethyl-N-(3-sulfopropyl)aniline or a salt thereof; and
an oxidase enzyme or a peroxidase enzyme or a mixture thereof, wherein the reagent composition is imbibed and dried into or onto the matrix material.
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Abstract
A dry chemistry reagent matrix composition is provided containing a matrix material and a reagent composition containing 3-methyl-6-(sulfonate salt)-benzothiazolinone-(2)-hydrazone (MBTH-S), N-ethyl-N-(3-sulfopropyl)aniline, and an oxidase enzyme or a peroxidase enzyme or a mixture thereof. The dry chemistry reagent matrix composition is useful in reagent test strips for determining the presence or concentration of an analyte in a fluid sample, such as blood.
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Citations
21 Claims
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1. A dry chemistry reagent matrix composition comprising a matrix material and a reagent composition comprising 3-methyl-6(M sulfonate)-benzothiazolinone-(2)-hydrazone (MBTH-S) where M is a positive ion providing a stable sulfonate salt;
- N-ethyl-N-(3-sulfopropyl)aniline or a salt thereof; and
an oxidase enzyme or a peroxidase enzyme or a mixture thereof, wherein the reagent composition is imbibed and dried into or onto the matrix material. - View Dependent Claims (2, 3, 4, 5, 6, 7)
- N-ethyl-N-(3-sulfopropyl)aniline or a salt thereof; and
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8. A device for testing a fluid for the presence or concentration of an analyte comprising:
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a support member comprising a matrix material; a dry chemistry reagent composition positioned on or impregnated in said support member, said reagent composition comprising 3-methyl-6(M sulfonate)-benzothiazolinone-(2)-hydrazone (MBTH-S) where M is a positive ion providing a stable sulfonate salt;
N-ethyl-N-(3-sulfopropyl)aniline or a salt thereof; and
an oxidase enzyme or a peroxidase enzyme or a mixture thereof;whereby the support member is adapted for receiving a fluid sample which contacts said composition and adapted for the support member to provide for inspection or reading of the color change produced by said reagent composition after contact with the fluid sample. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A method of testing a fluid for the presence or concentration of an analyte comprising:
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applying a fluid sample to a support member comprising a matrix material having positioned thereon or impregnated therein a dry chemistry reagent composition comprising 3-methyl-6(M sulfonate)-benzothiazolinone-(2)hydrazone (MBTH-S) where M is a positive ion providing a stable sulfonate salt;
N-ethyl-N-(3-sulfopropyl)aniline or a salt thereof; and
an oxidase enzyme or a peroxidase enzyme or a mixture thereof;
whereby the support member is adapted for receiving a fluid sample which contacts said reagent composition and adapted for the support member to provide for inspection or reading of the color change produced by said reagent composition after contact with the fluid sample; andreading or measuring the color indication provided by said reagent composition after contact with said fluid sample. - View Dependent Claims (16, 17, 18, 19, 20, 21)
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Specification