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Indole derivatives as 5-HT receptor antagonist

  • US 5,990,133 A
  • Filed: 10/16/1997
  • Issued: 11/23/1999
  • Est. Priority Date: 02/02/1995
  • Status: Expired due to Fees
First Claim
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1. A compound of formula (I) or a salt thereof:

  • ##STR11## wherein;

    P1 is pyridyl;

    P2 is phenyl;

    A is a bond or a chain of 1 to 5 atoms optionally substituted by C1-6 alkyl;

    R1 and R2 groups are each independently hydrogen, C1-6 alkyl optionally substituted by NR12 R13, C2-6 alkenyl, C2-6 alkynyl, cyano, halogen, CF3, NR12 R13, CHO, OCF3, COR14, CH2 OR14 or OR14 where R12, R13 and R14 are independently hydrogen or C1-6 alkyl;

    n and m are independently 0, 1 or 2;

    R3 is hydrogen or C1-6 alkyl;

    R4 is a group of formula (i);

    ##STR12## in which;

    R6 and R7 are independently hydrogen, C1-6 alkyl optionally substituted by one or more fluorine atoms, C1-6 alkylthio, C1-6 alkoxy or halogen, or a pharmaceutically acceptable salt thereof.

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