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Linker and linked fusion polypeptides

  • US 5,990,275 A
  • Filed: 09/10/1997
  • Issued: 11/23/1999
  • Est. Priority Date: 11/20/1992
  • Status: Expired due to Term
First Claim
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1. A linked fusion polypeptide comprising a first polypeptide and a second polypeptide connected by a peptide linker, wherein said peptide linker is 18 to 50 amino acid residues long, said peptide linker comprises one or more occurrences of a sequence XP wherein X is a charged amino acid, and said peptide linker comprises the sequence GSTSGSGXPGSGEGSTKG (SEQ. ID No. 1), said sequence positioned within said peptide linker so as to inhibit proteolysis of said linker by either subtilisin or trypsin.

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