System and method for measuring cardiac activity

• US 5,991,661 A
• Filed: 10/17/1997
• Issued: 11/23/1999
• Est. Priority Date: 10/17/1997
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Florio, Joseph J., Bradley, Kerry, Bornzin, Gene A., Park, Euljoon
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US08/954,326
• Time in Patent Office: 767 Days
• Field of Search: 607/9, 607/17, 607/19, 607/24, 607/25
• US Class Current: 607/19
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration

Abstract

An implantable cardiac stimulation device, such as a pacemaker or an implantable cardioverter-defibrillator, that includes an accelerometer-based activity sensor that processes one or more signals from the activity sensor to obtain parameters that are indicative of the heartbeat of the patient. The implantable cardiac stimulation device determines when the patient is at rest and the activity sensor provides a signal that corresponds to the acceleration of the sensor due to the heartbeat of the patient. This acceleration signal is integrated over time once to provide a contractility parameter, which is indicative of the contractility of the heart and is integrated over time twice to provide a displacement parameter, which is indicative of the displacement of the heart wall during the heartbeat. This displacement parameter is thereby indicative of the volume of blood pumped by the heart. A microprocessor uses either the contractility parameter, the displacement parameter or both to modify the delivery of therapeutic stimulation pulses to the heart.

Claims

1. An implantable cardiac stimulation device having a hermetically sealed housing, the device comprising:

pulse generating means for generating therapeutic stimulation pulses to a patient'"'"'s heart;

sensing means, mounted within the housing, for sensing acceleration of the cardiac wall resulting from the patient'"'"'s heartbeat and for providing a cardiac wall acceleration signal indicative thereof;

means for integrating the cardiac wall acceleration signal twice to produce a cardiac wall displacement signal; and

control means, coupled to the pulse generating means and the integrating means, for controlling the delivery of the therapeutic stimulation pulses to the patient'"'"'s heart and for altering the delivery of therapeutic stimulation pulses based, at least in part, on the cardiac wall displacement signal.

2. The implantable stimulation device of claim 1, wherein:

the sensing means includes means for sensing an activity level of the patient and for providing a body acceleration signal indicative thereof; and

the control means includes means for altering the delivery of therapeutic stimulation pulses based, at least in part, on the body acceleration signal.

3. The implantable stimulation device of claim 2, wherein:

the integrating means includes means for integrating the cardiac wall acceleration signal over time to produce a cardiac wall velocity signal corresponding to a contractility parameter of the heart; and

the control means includes means for altering the delivery of therapeutic stimulation pulses to the heart based upon the cardiac wall velocity signal.

4. The implantable stimulation device of claim 3, wherein the control means further comprises:

means for determining when the patient is at rest based on the body acceleration signal; and

means for triggering the integrating means to determine the cardiac wall velocity signal when the patient is at rest.

5. The implantable stimulation device of claim 1, wherein the control means further comprises:

means for determining when the patient is at rest based on the body acceleration signal; and

means for triggering the integrating means to determine the cardiac wall displacement signal when the patient is at rest.

6. A method of regulating the delivery of therapeutic electrical stimulation pulses to a patient'"'"'s heart from an implantable cardiac stimulation device having a housing with an accelerometer-based sensor mounted therein, the method comprising the steps of:

sensing a first acceleration signal corresponding to the mechanical contraction of the heart with the accelerometer-based sensor mounted in the housing;

processing the first acceleration signal to produce a cardiac wall displacement signal which is indicative of the volume of blood provided by the heart during a single heartbeat;

providing a first control signal based on the cardiac wall displacement signal; and

modifying the delivery of therapeutic stimulation pulses to the heart based, at least in part, on the first control signal.

7. The method of claim 6, further comprising the steps of:

sensing a second acceleration signal corresponding to a physical activity level of the patient;

providing a second control signal based on the second acceleration signal; and

modifying the delivery of therapeutic stimulation pulses to the heart based, at least in part, on the second control signal.

8. The method of claim 7, further comprising the steps of:

determining whether the patient is at rest based on the second acceleration signal; and

modifying the delivery of therapeutic stimulation pulses to the heart based, at least in part, on the first control signal when the patient is at rest.

9. The method of claim 8, further comprising the steps of:

integrating the first acceleration signal over time to produce a cardiac wall velocity signal that corresponds to a contractility parameter of the heart; and

providing a third control signal based on the cardiac wall velocity signal.

10. The method of claim 7, wherein the step of modifying the delivery of therapeutic stimulation pulses to the heart further comprises the step of:

adjusting the rate of the stimulation pulses based on at least one of the first and second control signals.

11. The method of claim 7, wherein the step of modifying the delivery of therapeutic stimulation pulses to the heart further comprises the steps of:

generating stimulation pulses in the patient'"'"'s atrium and in the patient'"'"'s ventricle, the stimulation pulses being separated by an A-V Delay interval; and

adjusting the A-V Delay interval based on the first control signal.

12. The method of claim 6, wherein the step of modifying the delivery of therapeutic stimulation pulses comprises the step of:

modifying the delivery of therapeutic stimulation pulses to optimize the performance of the heart so that a maximum volume of blood is pumped by the heart during each heartbeat.

13. An implantable cardiac stimulation device having a hermetically sealed housing, the device comprising:

pulse generating means for generating therapeutic stimulation pulses to a patient'"'"'s heart;

sensing means, mounted within the housing, for sensing acceleration and for providing an acceleration signal indicative thereof;

detection means for detecting a low amplitude component of the acceleration signal corresponding to heart wall acceleration resulting from the patient'"'"'s heartbeat;

integrating means for integrating the low amplitude component of the acceleration signal twice to produce a first control signal corresponding to a physical displacement of the cardiac wall of the heart; and

control means, coupled to the pulse generating means and the integrating means, for controlling the delivery of the therapeutic stimulation pulses to the patient'"'"'s heart and for altering the delivery of therapeutic stimulation pulses based, at least in part, on the first control signal.

14. The implantable stimulation device of claim 13, wherein:

the detection means includes means for detecting a high amplitude component of the acceleration signal corresponding to an activity level of the patient; and

the control means includes means for altering the delivery of therapeutic stimulation pulses based, at least in part, on the high amplitude component of the acceleration signal.

15. The implantable stimulation device of claim 14, wherein the sensing means comprises:

an accelerometer-based activity sensor that is responsive to both the acceleration of the heart wall due to the contraction of the heart and to body motion.

16. The implantable stimulation device of claim 13, further comprising:

means for integrating the low amplitude component of the acceleration signal over time to produce a second control signal corresponding to a contractility parameter of the heart; and

wherein the control means includes means for altering the delivery of therapeutic stimulation pulses to the heart based upon the second control signal.

17. The implantable stimulation device of claim 16, wherein the control means further comprises:

means for determining when the patient is at rest based on the high amplitude component of the acceleration signal; and

means for triggering the integrating means to integrate the low amplitude component of the acceleration signal when the patient is at rest.

18. The implantable stimulation device of claim 13, wherein the control means further comprises:

means for determining when the patient is at rest based on the high amplitude component of the acceleration signal; and

means for triggering the integrating means to twice integrate the low amplitude component of the acceleration signal when the patient is at rest.

19. The implantable stimulation device of claim 13, wherein the housing is of the type which is implantable beneath the pectoral muscle of the patient.

20. An implantable cardiac stimulation device having a hermetically-sealed housing, the device comprising:

an accelerometer, mounted within the housing, that senses acceleration of the cardiac wall resulting from a patient'"'"'s heartbeat, the accelerometer producing a cardiac wall acceleration signal as an output;

signal processing circuitry, coupled to the accelerometer, that integrates the cardiac wall acceleration signal twice to produce a cardiac wall displacement signal;

a pulse generator circuit that generates stimulation pulses to the patient'"'"'s heart in response to a trigger signal which defines a timing between the stimulation pulses; and

a control circuit, coupled to the pulse generator circuit and the signal processing circuitry, configured to modulate the timing of the stimulation pulses in response to the cardiac wall displacement signal.

21. The implantable stimulation device of claim 20, wherein:

the signal processing circuitry further comprises;

circuitry for processing the accelerometer to determine a body acceleration signal due to body motion of the patient during exercise;

a detection circuit for determining when the patient is at rest and when the patient is exercising based on the body acceleration signal; and

the control circuit modulates the timing of stimulation pulses based on the body acceleration signal when the patient is exercising and further modulates the rate of stimulation pulses based on the cardiac wall displacement signal when the patient is at rest.

22. The implantable stimulation device of claim 21, wherein:

the timing of the stimulation pulses includes a base rate timing; and

the control circuit further includes circuitry to determine an optimal base rate timing of stimulation pulses.

23. The implantable stimulation device of claim 21, wherein:

the timing of the stimulation pulses includes an A-V timing; and

the control circuit further includes circuitry to determine an optimal A-V timing of stimulation pulses.