Microcapsules for site-specific delivery
First Claim
1. A two-component microcapsule for therapeutic or diagnostic use comprising:
- a first part comprising a transient radioactive central core; and
a second part comprising a transient single-piece outer shell surrounding the central core;
wherein the microcapsule has a diameter within the range of from about 5 microns to about 50 microns, and the central core and the outer shell break down in an aqueous environment into biologically compatible break down products.
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0 Petitions
Accused Products
Abstract
Disclosed is a site specific microcapsule delivery system and microcapsules for delivering one or more active agents to a preselected site. The system includes a catheter and microcapsules. A preferred embodiment of the catheter includes an inner inflatable balloon having an outer perforated delivery balloon concentrically disposed thereon. The microcapsule preferably comprises a water dissolvable core, and at least one outer protective shell. In a preferred embodiment, the core comprises phosphorous 31 and the outer shell comprises PGLA or other water soluble material. Neutron beam activation of the core produces phosphorous 32, for emitting therapeutic radiation to the treatment site. The outer protective shell dissipates over time, and, following a predetermined delivery period, the outer shell is removed and the central core dissipates to leave only biologically compatible break down products.
115 Citations
18 Claims
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1. A two-component microcapsule for therapeutic or diagnostic use comprising:
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a first part comprising a transient radioactive central core; and a second part comprising a transient single-piece outer shell surrounding the central core;
wherein the microcapsule has a diameter within the range of from about 5 microns to about 50 microns, and the central core and the outer shell break down in an aqueous environment into biologically compatible break down products. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A two-component microcapsule for therapeutic or diagnostic use comprising:
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a first part comprising a transient radioactive central core; and a second part comprising a transient single-piece outer shell surrounding the central core;
wherein the central core and the outer shell break down in an aqueous environment into biologically compatible break down products;wherein the thickness of the outer shell is within the range of from about 1 micron to about 15 microns. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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Specification