Method of measuring intracranial pressure

• US 5,993,398 A
• Filed: 04/10/1998
• Issued: 11/30/1999
• Est. Priority Date: 04/10/1998
• Status: Expired due to Term

• Current Assignee: Noam Alperin
• Original Assignee: Noam Alperin
• Inventors: Alperin, Noam
• Primary Examiner(s): O'Connor, Cary
• Assistant Examiner(s): WINGOOD, PAMELA LYNN
• Application Number:
  US09/058,484
• Time in Patent Office: 599 Days
• Field of Search: 600/561, 600/562, 600/573, 600/587, 600/594, 600/595
• US Class Current: 600/561
• CPC Class Codes: A61B 5/031 Intracranial pressure
• CPC Class Codes: A61B 5/407 Evaluating the spinal cord A61B5/4896 takes precedence
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography

Abstract

A method and apparatus are provided for measuring intracranial pressure. The method includes the steps of measuring arterial inflow, venous outflow and cranial spinal fluid flow and calculating an intracranial volume change from the measured arterial inflow, venous outflow and cranial spinal fluid flow. The method also includes the steps of calculating a pressure gradient of spinal fluid flow from the measured cranial spinal fluid flow and calculating a pressure change per unit volume change based upon the calculated intracranial volume change and cranial pressure gradient.

Claims

1. A method of measuring intracranial pressure comprising the steps of:

measuring arterial inflow, venous outflow and cranial spinal fluid flow;

calculating an intracranial volume change over a cardiac cycle from the measured arterial inflow, venous outflow and cranial spinal fluid flow;

calculating a pressure gradient over a cardiac cycle of spinal fluid flow from the measured cranial spinal fluid flow; and

calculating a pressure change per unit volume change based upon the calculated intracranial volume change and cranial pressure gradient.

2. The method of measuring intracranial pressure as in claim 1 wherein the step of measuring further comprises measuring spinal cord movement.

3. The method of measuring intracranial pressure as in claim 2 wherein the step of measuring a cranial spinal fluid flow and spinal cord movement further comprises determining a cross-sectional area of the spinal cord and an annular area between the spinal cord and a dura matter of the spinal cord.

4. The method of measuring intracranial pressure as in claim 3 wherein the step of measuring the area of the spinal cord and annular area further comprises forming a magnetic resonance image and integrating an area of the spinal cord and the annular area between the spinal cord and dura matter.

5. The method of measuring intracranial pressure as in claim 4 wherein the step of measuring a cranial spinal fluid flow and spinal cord oscillatory flow further comprises measuring a velocity of the cranial spinal fluid flow velocity across the annular area between the spinal cord and the dura matter and a velocity of the spinal cord.

6. The method of measuring intracranial pressure as in claim 5 wherein the step of measuring cranial spinal fluid flow and spinal cord oscillatory flow further comprises forming a magnetic resonance image and determining a velocity of the cranial spinal fluid flow within the annular space.

7. The method of measuring intracranial pressure as in claim 6 wherein the step of calculating a pressure gradient of spinal fluid flow further comprises calculating a pressure gradient using the Navier-Stokes equation based upon the determined size of the annular area and determined velocity of the cranial spinal fluid flow.

8. The method of measuring intracranial pressure as in claim 6 wherein the step of measuring a cranial pressure gradient further comprises calculating a pressure gradient using the Womersley Pressure-Flow Relation based upon the determined annular size and determined velocity of the cranial spinal fluid flow.

9. The method of measuring intracranial pressure as in claim 1 wherein the step of measuring arterial inflow and venous outflow further comprises determining a cross-sectional area of two carotid and two vertebral arteries and two jugular veins.

10. The method of measuring intracranial pressure as in claim 9 wherein the step of measuring a cross-sectional area further comprises forming a magnetic resonance image and integrating an area within two carotid and two vertebral arteries and two jugular veins.

11. The method of measuring intracranial pressure as in claim 10 wherein the step of measuring arterial inflow and venous outflow further comprises determining a velocity of blood flow in two carotid and two vertebral arteries and two jugular veins.

12. The method of measuring intracranial pressure as in claim 11 wherein the step of measuring arterial inflow and venous outflow further comprises forming a magnetic resonance image and determining blood velocity within two carotid and two vertebral arteries and two jugular veins.

13. Apparatus for measuring intracranial pressure comprising:

means for measuring arterial inflow, venous outflow and cranial spinal fluid flow;

means for calculating an intracranial volume change over a cardiac cycle from the measured arterial inflow, venous outflow and cranial spinal fluid flow;

means for calculating a pressure gradient over a cardiac cycle of spinal fluid flow from the measured cranial spinal fluid flow; and

means for calculating a pressure change per unit volume change based upon the calculated intracranial volume change and cranial pressure gradient.

14. The apparatus for measuring intracranial pressure as in claim 13 further comprising means for calculating spinal cord movement.

15. The apparatus for measuring intracranial pressure as in claim 14 wherein the means for measuring a cranial spinal fluid flow and spinal cord movement flow further comprises means for determining a cross-sectional size of the spinal cord and an annular area between the spinal cord and a dura matter of the spinal cord.

16. The apparatus for measuring intracranial pressure as in claim 15 wherein the means for measuring the size of the spinal cord and annular area further comprises means for forming a magnetic resonance image and integrating an area of the spinal cord and the annular area between the spinal cord and dura matter.

17. The apparatus for measuring intracranial pressure as in claim 16 wherein the means for measuring a cranial spinal fluid flow and spinal cord oscillatory flow further comprises means for measuring a velocity of the cranial spinal fluid flow velocity across the annular area between the spinal cord and the dura matter and a velocity of the spinal cord.

18. The apparatus for measuring intracranial pressure as in claim 17 wherein the means for measuring cranial spinal fluid flow and spinal cord oscillatory flow further comprises means for forming a magnetic resonance image and determining a velocity of the cranial spinal fluid flow within the annular space.

19. The apparatus for measuring intracranial pressure as in claim 18 wherein the means for calculating a pressure gradient of spinal fluid flow further comprises means for calculating a pressure gradient using the Navier-Stokes equation based upon the determined size of the annular area and determined velocity of the cranial spinal fluid flow.

20. The apparatus for measuring intracranial pressure as in claim 19 wherein the means for measuring a cranial pressure gradient further comprises means for calculating a pressure gradient using the Womersley Pressure-Flow Relation based upon the determined annular size and determined velocity of the cranial spinal fluid flow.

21. The apparatus for measuring intracranial pressure as in claim 14 wherein the means for measuring arterial inflow and venous outflow further comprises means for determining a cross-sectional area of two carotid and two vertebral arteries and two jugular veins.

22. The apparatus for measuring intracranial pressure as in claim 21 wherein the means for measuring a cross-sectional area further comprises means for forming a magnetic resonance image and integrating an area within two carotid and two vertebral arteries and two jugular veins.

23. The apparatus for measuring intracranial pressure as in claim 22 wherein the means for measuring arterial inflow and venous outflow further comprises means for determining a velocity of blood flow in two carotid and two vertebral arteries and two jugular veins.

24. The apparatus for measuring intracranial pressure as in claim 23 wherein the means for measuring arterial inflow and venous outflow further comprises means for forming a magnetic resonance image and determining blood velocity within two carotid and two vertebral arteries and two jugular veins.