Fluid dispenser with reservoir fill assembly

• US 5,993,425 A
• Filed: 04/15/1998
• Issued: 11/30/1999
• Est. Priority Date: 04/15/1998
• Status: Expired due to Fees

• Current Assignee: Pescadero Beach Holdings Corporation
• Original Assignee: Science Incorporated
• Inventors: Kriesel, Marshall S.
• Primary Examiner(s): Hirsch, Paul J.
• Application Number:
  US09/060,852
• Time in Patent Office: 594 Days
• Field of Search: 604/132, 604/191, 604/187
• US Class Current: 604/191
• CPC Class Codes: A61M 2209/045 for filling, e.g. for filling reservoirs
• CPC Class Codes: A61M 5/152 pressurised by contraction of elastic reservoirs containers for dispensing contents by contraction of an elastic bag provided therein, in general B65D83/0061

Abstract

An apparatus for delivering medicaments to a patient which include a fluid dispensing device and a novel cooperating reservoir fill assembly which can be easily and quickly connected to the fluid dispensing device. The fluid dispensing device uniquely includes an elastomeric bladder stored energy type infusion means which can be used for delivering a wide variety of medicaments such as drugs, medicaments, bilogical agents, or other therapeutic agents at a substantially constant rate.

Claims

1. An apparatus for use in infusing medicinal fluid into a patient at a controlled rate comprising:

(a) a fluid dispenser comprising;

(i) an elongate housing having walls defining an internal chamber;

(ii) a support connected to said housing, said support being disposed within said internal chamber and having a dispenser connector and a fluid inlet and a fluid outlet; and

(iii) an elongate tubular shaped elastomeric member connected proximate its ends to said support, said elastomeric member having a central portion disposed within said internal chamber of said housing and overlaying said fluid inlet and said fluid outlet of said support, said central portion of said elastomeric member being distendable by fluid flowing through said fluid inlet of said support from a first position in proximity with said support to a second position; and

(b) a reservoir fill assembly interconnectable with said fluid dispenser for filling said fluid reservoir thereof, said reservoir fill assembly comprising;

(i) a container subassembly including a container having a fluid chamber;

closure means for sealably closing said first open end of said container; and

a plunger movable relative to said container from a first location to a second, spaced-apart location;

(ii) an adapter subassembly comprising a hollow housing having a first open end for receiving a part of said container of said container assembly and a second end, said hollow housing further including an adapter connector mateably interconnectable with said dispenser connector for removably interconnecting said adapter subassembly with said fluid dispenser; and

(iii) an adapter sleeve interconnectable with said adapter subassembly for movement between first and second positions, said adapter sleeve including pusher means for engagement with said plunger of said container subassembly to move said plunger between said first and second locations upon movement of said adapter sleeve toward said second position.

2. An apparatus as defined in claim 1 in which said fluid dispenser further includes dispenser flow control means for controlling fluid flow from said fluid outlet of said support.

3. An apparatus as defined in claim 1 in which said adapter subassembly includes fill flow control means including valve means for controlling fluid flow from said container subassembly toward said fluid inlet of said support.

4. An apparatus as defined in claim 3 in which said valve means comprises a valve seat formed in said adapter connector and a valve member disposed within said adapter connector for movement between a first position in sealing engagement with said valve seat to a second position spaced apart from said valve seat.

5. An apparatus for use in infusing medicinal fluid into a patient at a controlled rate comprising:

(a) a fluid dispenser comprising;

(i) an elongate housing having walls defining an internal chamber;

(ii) a support connected to said housing, said support being disposed within said internal chamber and having a dispenser connector and a fluid inlet and a fluid outlet;

(iii) an elastomeric member connected to said support, said elastomeric member having a central portion disposed within said internal chamber of said housing and overlaying said fluid inlet and said fluid outlet of said support said central portion of said elastomeric member being distendable by fluid flowing through said fluid inlet of said support from a first position in proximity with said support to a second position; and

(iv) dispenser flow control means for controlling fluid flow toward said fluid outlet; and

(b) a reservoir fill assembly interconnectable with said fluid dispenser for filling said fluid reservoir thereof, said reservoir fill assembly comprising;

(i) a container subassembly including a container having a body portion, a fluid chamber, and first and second open ends;

a pierceable septum for sealably closing said first open end of said container; and

a plunger telescopically movable within said container from a first location proximate said second open end to a second, spaced-apart location;

(ii) an adapter subassembly comprising a hollow housing having a cannula for piercing said pierceable septum;

an annular passageway;

a first open end for telescopically receiving at least a part of said body portion of said container of said container assembly; and

a second end, said hollow housing further including an adapter connector mateably interconnectable with said dispenser connector for removably interconnecting said adapter subassembly with said fluid dispenser; and

(iii) an adapter sleeve interconnectable with said adapter subassembly for movement between a first position and a second position, said adapter sleeve including pusher means for engagement with said plunger of said container subassembly to move said plunger within said container between said first and second locations as said adapter sleeve moves toward said second position.

6. An apparatus as defined in claim 5 in which said dispenser flow control means comprises a permeable porous member.

7. An apparatus as defined in claim 5 in which said support is provided with an internal chamber and in which said flow control means comprises a porous member disposed within said internal chamber.

8. An apparatus as defined in claim 5 in which said adapter subassembly includes fill flow control means including valve means for controlling fluid flow from said container subassembly toward said fluid inlet of said support.

9. An apparatus as defined in claim 8 in which said valve comprises a valve member carried by said adapter subassembly for movement between a first position and a second position.

10. An apparatus as defined in claim 8 in which said closure means of said container subassembly comprises an elastomeric septum and in which said fill flow control means comprises a hollow cannula.

11. An apparatus as defined in claim 10 in which said fill flow control means comprises valve means in fluid communication with said hollow cannula.

12. An apparatus as defined in claim 10 in which said elastomeric septum comprises a non-corable material and in which said hollow cannula comprises a sharp-end cannula.

13. An apparatus as defined in claim 10 in which said elastomeric septum is slitted and in which said hollow cannula comprises a blunt-end cannula.

14. An apparatus as defined in claim 10 in which said closure means of said container subassembly further includes a clamping ring for crimping engagement with said container to hold said elastomeric septum in place.

15. An apparatus for use in infusing medicinal fluid into a patient at a controlled rate comprising:

(a) a fluid dispenser comprising;

(i) an elongate housing having walls defining an internal chamber;

(ii) a support connected to said housing, said support being disposed within said internal chamber and having a dispenser connector, a fluid inlet and a fluid outlet;

(iii) an elastomeric member connected to said support, said elastomeric member having a central portion disposed within said internal chamber of said housing and overlaying said fluid inlet and said fluid outlet of said support said central portion of said elastomeric member being distendable by fluid flowing through said fluid inlet of said support from a first position in proximity with said support to a second position; and

(iv) dispenser flow control means for controlling fluid flow toward said fluid outlet; and

(b) a reservoir fill assembly interconnectable with said fluid dispenser for filling said fluid reservoir thereof, said reservoir fill assembly comprising;

(i) a first container subassembly including a container having a body portion, a fluid chamber, and first and second open ends;

an elastomeric septum for sealably closing said first open end of said container; and

a plunger telescopically movable within said container from a first location proximate said second open end to a second, spaced-apart location;

(ii) an adapter subassembly comprising a hollow housing having a first annular passageway and a first open end for telescopically receiving at least a part of said body portion of said container of said container assembly and a second end portion including a hollow cannula adapted to pierce said elastomeric septum, said hollow housing further including an adapter connector mateably interconnectable with said dispenser connected for removably interconnecting said adapter subassembly with said fluid dispenser; and

(iii) an adapter sleeve interconnectable with said adapter subassembly, said adapter sleeve including pusher means for engagement with said plunger of said container of said first container subassembly to move said plunger within said container between said first and second locations.

16. An apparatus as defined in claim 15 in which said dispenser flow control means comprises a porous member.

17. An apparatus as defined in claim 15 in which said dispenser flow control means comprises a filter and a wafer-like element having a microbore formed therein.

18. An apparatus as defined in claim 15 in which said dispenser flow control means comprises a two-stage, flow control including a filter, a porous member, and a thin element having a microbore formed centrally thereof.

19. An apparatus as defined in claim 15 in which said adapter subassembly further includes valve means for controlling fluid flow from said first container subassembly toward said fluid inlet of said support.

20. An apparatus as defined in claim 15 in which said hollow cannula comprises a blunt end cannula and in which said elastomeric septum includes a slit body portion.

21. An apparatus as defined in claim 15 in which said reservoir fill assembly further comprises a second container subassembly and in which said adapter subassembly comprises a hollow housing having a second annular passageway for receiving at least a portion of said second container subassembly.

22. An apparatus as defined in claim 21 further including a second adapter sleeve interconnectable with said adapter subassembly.

23. An apparatus as defined in claim 22 in which said reservoir fill assembly includes locking means for locking said first and second adapter sleeves to said adapter subassembly.

24. An apparatus for use in infusing medicinal fluid into a patient at a controlled rate comprising:

(a) a fluid dispenser comprising;

(i) an elongate housing having walls defining an internal chamber;

(ii) a support connected to said housing, said support being disposed within said internal chamber and having a dispenser connector and a fluid inlet and a fluid outlet;

(iii) an elongate tubular shaped elastomeric member connected proximate its ends to said support, said elastomeric member having a central portion disposed within said internal chamber of said housing and overlaying said fluid inlet and said fluid outlet of said support, said central portion of said elastomeric member being distendable by fluid flowing through said fluid inlet of said support from a first position in proximity with said support to a second position; and

(iv) dispenser flow control means for controlling fluid flow toward said fluid outlet of said support; and

(b) a reservoir fill assembly interconnectable with said fluid dispenser for filling said fluid reservoir thereof, said reservoir fill assembly comprising;

(i) a container subassembly including a container having a body portion, a fluid chamber, and first and second open ends;

a pierceable septum for sealably closing said first open end of said container and a plunger telescopically movable within said container from a first location proximate said second open end to a second, spaced-apart location;

(ii) an adapter subassembly comprising a hollow housing having an annular passageway and a first open end for telescopically receiving a part of said body portion of said container of said container subassembly and a second end provided with a hollow cannula for piercing said pierceable septum, said hollow housing further including an adapter connector mateably interconnectable with said dispenser connector of said base of said housing assembly for removably interconnecting said adapter subassembly with said fluid dispenser; and

(iii) an adapter sleeve telescopically receivable within said annular passageway of said hollow housing said sleeve subassembly including pusher means for engagement with said plunger to move said plunger within said container between said first and second locations.

25. A device as defined in claim 24 in which said dispenser flow control means comprises a porous member carried by said support of said fluid dispenser.

26. A device as defined in claim 24 in which said dispenser flow control means comprises a thin, wafer-like element having a microbore formed therein.

27. A device as defined in claim 24 in which said dispenser flow control means for controlling fluid flow from said fluid outlet port of said support comprises a hollow cannula.

28. A device as defined in claim 24 in which said dispenser flow rate control means comprises a hollow piercing cannula.

29. A device as defined in claim 24 in which said dispenser flow rate control means comprises a blunt-end hollow cannula.

30. A device as defined in claim 24 in which said dispenser flow rate control means comprises a laser drilled wafer and a backup flow rate control means comprising a porous member.

31. A device as defined in claim 24 in which said reservoir fill assembly further includes fill flow control means, said fill flow control means comprising a valve member carried by said hollow housing.

32. A device as defined in claim 31 in which said fill flow control means comprises a septum carried by said adapter subassembly.

33. A device as defined in claim 31 in which said fill flow control means comprises a slit septum carried by said adapter subassembly.

34. An apparatus for use in infusing medicinal fluid into a patient at a controlled rate comprising:

(a) a fluid dispenser comprising;

(i) an elongate housing having walls defining an internal chamber;

(ii) a support connected to said housing, said support being disposed within said internal chamber and having a dispenser connector and a fluid inlet and a fluid outlet; and

(iii) an elongate tubular shaped elastomeric member connected proximate its ends to said support, said elastomeric member having a central portion disposed within said internal chamber of said housing and overlaying said fluid inlet and said fluid outlet of said support, said central portion of said elastomeric member being distendable by fluid flowing through said fluid inlet of said support from a first position in proximity with said support to a second position; and

(b) a reservoir fill assembly interconnectable with said fluid dispenser for filling said fluid reservoir thereof, said reservoir fill assembly comprising;

(i) a container subassembly, including a container having a fluid chamber and a plunger movable relative to said fluid chamber from a first location to a second spaced-apart location;

(ii) an adapter subassembly comprising a hollow housing having a fluid outlet, an outer wall and an inner wall defining therebetween a generally annular shaped passageway for containing a fluid, said inner wall having a first open end for telescopically receiving at least a part of said container of said container subassembly and a second end, said hollow housing further including connector means for connecting said adapter subassembly with the fluid dispenser; and

(iii) an adapter sleeve mateable with said adapter subassembly including means for engagement with said plunger of said container subassembly to move said plunger between said first and second locations and further including a generally ring shaped member sealably received within said annular shaped passageway for urging fluid contained within said passageway outwardly thereof toward said fluid outlet of said hollow housing.

35. An apparatus as defined in claim 34 in which said inner wall of said adapter subassembly is generally circular in cross section and in which said outer wall thereof is generally elliptical in cross section.

36. An apparatus as defined in claim 34 in which said container subassembly includes a pierceable septum and in which said hollow housing of said adapter subassembly includes a hollow cannula for piercing said septum.

37. An apparatus as defined in claim 34 in which said adapter subassembly includes valve means for controlling fluid flow toward said fluid outlet thereof.

38. An apparatus as defined in claim 34 in which the fluid dispenser includes a septum and in which said adapter subassembly of said reservoir fill assembly includes a second hollow cannula for piercing a septum of the fluid dispenser.

39. An apparatus as defined in claim 34 in which said fluid dispenser includes a hollow cannula and in which said adapter subassembly of said reservoir fill assembly includes a septum pierceable by the hollow cannula of the fluid dispenser.

40. A reservoir fill assembly as defined in claim 39 in which said septum of said adapter subassembly comprises a slit septum.

41. An apparatus for use in infusing medicinal fluid into a patient at a controlled rate comprising:

(a) a fluid dispenser comprising;

(i) an elongate housing having walls defining an internal chamber;

(ii) a support connected to said housing, said support being disposed within said internal chamber and having a dispenser connector and a fluid inlet and a fluid outlet; and

(iii) an elongate tubular shaped elastomeric member connected proximate its ends to said support, said elastomeric member having a central portion disposed within said internal chamber of said housing and overlaying said fluid inlet and said fluid outlet of said support, said central portion of said elastomeric member being distendable by fluid flowing through said fluid inlet of said support from a first position in proximity with said support to a second position; and

(b) a reservoir fill assembly interconnectable with said fluid dispenser for filling said fluid reservoir thereof, said reservoir fill assembly comprising;

(i) a container subassembly including first and second containers each having a fluid chamber and a plunger movable relative to said fluid chamber from a first location to a second, spaced-apart location;

(ii) an adapter subassembly comprising a hollow housing having a fluid outlet, an outer wall and further including;

a. a first inner wall defining, in conjunction with said outer wall, a first generally annular-shaped passageway, said first inner wall having a first open end for telescopically receiving at least a portion of said first container of said container subassembly; and

b. a second inner wall defining in conjunction with said outer wall a second generally annular shaped passageway, said second inner wall having a first open end for telescopically receiving at least a portion of said second container of said container subassembly;

(iii) an adapter sleeve mateable with said adapter subassembly including first means for engagement with said plunger of said first container of said container subassembly to move said plunger between said first and second locations and further including second means for engagement with said plunger of said second container of said container subassembly to move said plunger between said first and second locations.