Method of treatment using electroporation mediated delivery of drugs and genes
First Claim
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1. A method for the therapeutic application of electroporation to a portion of the body of a patient for introducing molecules into tissues therein, comprising:
- providing an array of multiple opposed pairs of electrodes connected to a generator, wherein at least two pairs of electrodes are activated simultaneously, at least one of said pairs of electrodes having a needle configuration for penetrating tissue;
inserting a first pair of said needle electrodes into selected tissue for introducing molecules into the tissue;
positioning a second pair of electrodes of said array of electrodes in conductive relation to said selected tissue so that said tissue is between said first and second opposed pairs of electrodes; and
separately applying pulses of high amplitude electric signals to at least two different pairs of electrodes, but not all electrodes simultaneously and proportionately to the distance between said pairs of electrodes causing in vivo electroporation of the tissue.
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Abstract
A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
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Citations
12 Claims
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1. A method for the therapeutic application of electroporation to a portion of the body of a patient for introducing molecules into tissues therein, comprising:
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providing an array of multiple opposed pairs of electrodes connected to a generator, wherein at least two pairs of electrodes are activated simultaneously, at least one of said pairs of electrodes having a needle configuration for penetrating tissue; inserting a first pair of said needle electrodes into selected tissue for introducing molecules into the tissue; positioning a second pair of electrodes of said array of electrodes in conductive relation to said selected tissue so that said tissue is between said first and second opposed pairs of electrodes; and separately applying pulses of high amplitude electric signals to at least two different pairs of electrodes, but not all electrodes simultaneously and proportionately to the distance between said pairs of electrodes causing in vivo electroporation of the tissue. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for the in vivo electroporation-mediated therapy of a cell of a subject comprising:
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administering a therapeutic composition to the subject such that the composition is delivered to the cell; providing an array of multiple opposed pairs of electrodes connected to a generator, wherein at least two pairs of electrodes are activated simultaneously, at least one of said pairs of electrodes having a needle configuration for penetrating tissue; inserting a first pair of said needle electrodes into selected tissue for introducing molecules into the cell; positioning a second pair of electrodes of said array of electrodes in conductive relation to said selected tissue so that said cell is between said first and second opposed pairs of electrodes; and separately applying electrical pulses of short duration to at least two different pairs of electrodes, but not all electrodes simultaneously and proportionately to the distance between said electrodes causing in vivo electroporation of a cell of the tissue. - View Dependent Claims (8, 9, 10, 11, 12)
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Specification