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Method of purifying and identifying a large multiplicity of chemical reaction products simultaneously

  • US 5,993,662 A
  • Filed: 08/28/1998
  • Issued: 11/30/1999
  • Est. Priority Date: 08/28/1998
  • Status: Expired due to Fees
First Claim
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1. A system of simultaneously purifying a multiplicity of solutions of chemical reaction products using liquid chromatography and identifying sought-after products using mass spectrometry, while tracking chemicals present in individual reaction products using computer memory, the system comprising:

  • (a) selecting an array of a multiplicity of reaction tubes, each tube containing a solution, of a chemical reaction product, each tube coded with an identifying code, the code stored in a memory of a digital signal processor to identify the chemical reaction product;

    (b) subjecting at least some of the multiplicity of reaction products separately and simultaneously to liquid chromatography to produce a chromatograph for each, the chromatograph comprising a series of peaks representing individual chemical compounds contained in each reaction product;

    (c) automatically collecting individual chemical compounds corresponding to peaks of the chromatographs of the plurality of the reaction products into an array of separate purified chemical compound tubes and coding with a second code, traceable to the identifying code of the reaction product from which the purified compound is obtained, the second code stored in a computer database;

    (d) simultaneously sampling a multiplicity of the purified compound tubes while maintaining tracking correspondence between each sample and each purified compound tube and subjecting each of the samples separately to mass spectrometric analysis; and

    (e) comparing output from the mass spectrometric analysis for each sample with data identifying known compounds expected to be present in the reaction products, the data stored in a database of a digital signal processor, to identify samples as containing particular chemical compounds.

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