Anti-carious chewing gums, candies, gels, toothpastes and dentifrices
First Claim
1. A remineralizing composition in the form of a gel, toothpaste or dentifrice comprising, in combination:
- a toothpaste or dentifrice mixed with a sparingly soluble calcium phosphate salt in dry particle form, said salt capable of sustained release of both calcium and phosphate ions into saliva upon exposure of the particle thereto and providing a hydroxyapatite remineralization, said salt selected from the group consisting essentially of tetracalcium phosphate,∝
tricalcium phosphate and monocalcium phosphate.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention relates to anticarious delivery vehicles, specifically chewing gums, candies, confectioneries, toothpastes, dentifrices and gels. The invention specifically provides chewing gums, candies, confectioneries, toothpastes, dentifrices and gels containing non-toxic sparingly soluble calcium and phosphate compounds as additives, causing the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than 5 minutes. The invention provides released calcium phosphate ions that diffuse into partially demineralized tooth enamel or dentin, leading to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. The invention thus provides agents and methods for remineralization of teeth and for reducing or eradicating cariogenic challenge in plaque following sucrose intake. The formulations of the invention can thereby produce effective anticaries actions without the use of fluoride. In addition, the formulations of the invention can be used to desensitize hypersensitive teeth.
-
Citations
29 Claims
-
1. A remineralizing composition in the form of a gel, toothpaste or dentifrice comprising, in combination:
a toothpaste or dentifrice mixed with a sparingly soluble calcium phosphate salt in dry particle form, said salt capable of sustained release of both calcium and phosphate ions into saliva upon exposure of the particle thereto and providing a hydroxyapatite remineralization, said salt selected from the group consisting essentially of tetracalcium phosphate,∝
tricalcium phosphate and monocalcium phosphate.- View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
-
2. A gel, toothpaste or dentifrice remineralization system comprising, in combination:
a sparingly soluble calcium compound and a separate phosphate salt, said compound and said salt each separately combined with a separate gel, toothpaste or dentifrice, said compound and said salt capable, respectively, of sustained release of calcium and phosphorous ions in the presence of water for at least about 1-5 minutes thereby forming hydroxyapatite as an end product when said gel, toothpaste or dentifrice containing, respectively, said salt and said compound are mixed in the presence of water. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
Specification