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Method and means for producing high titer, safe, recombinant lentivirus vectors

  • US 5,994,136 A
  • Filed: 12/12/1997
  • Issued: 11/30/1999
  • Est. Priority Date: 12/12/1997
  • Status: Expired due to Term
First Claim
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1. A human immunodeficiency virus (HIV) transfer vector comprising a 5'"'"' LTR and a 3'"'"' LTR, each of which contains a U3 region, wherein a part or all of a regulatory element of the U3 region of the 5'"'"' LTR is replaced by another regulatory element, operable in a mammalian cell, which is not endogenous to said HIV.

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