Amelioration of apomorphine adverse effects
First Claim
1. A method of minimizing adverse effects of apomorphine on a human patient comprising the steps of:
- (a) administering to a human patient a threshold dose of about 2 to about 8 mg of apomorphine;
(b) administering to the human patient a series of increasing periodic doses of apomorphine greater than the threshold dose until a final apomorphine dose in excess of a therapeutic dose has been received by the human patient; and
thereafter(c) administering to the human patient a therapeutic dose of apomorphine.
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Accused Products
Abstract
Symptoms of Parkinson'"'"'s disease and psychogenic male erectile dysfunction (MED) can be ameliorated through the use of apomorphine. The adverse side effects of apomorphine administration, such as nausea, vomiting, yawning, and cardiovascular effects, can be significantly reduced by a dose escalating method of acclimatization. An initial dose of apomorphine is administered to the patient, and subsequently increased over a period of time until a final apomorphine dose in excess of a desired therapeutic dose has been received by the patient. Thereafter a therapeutic dose of apomorphine, less than the final apomorphine dose, is administered to the patient with attendant reduced side effects.
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Citations
23 Claims
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1. A method of minimizing adverse effects of apomorphine on a human patient comprising the steps of:
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(a) administering to a human patient a threshold dose of about 2 to about 8 mg of apomorphine; (b) administering to the human patient a series of increasing periodic doses of apomorphine greater than the threshold dose until a final apomorphine dose in excess of a therapeutic dose has been received by the human patient; and
thereafter(c) administering to the human patient a therapeutic dose of apomorphine. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of minimizing adverse effects of apomorphine on a male patient comprising the steps of:
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(a) administering to the male patient a sublingual threshold dose of apomorphine; (b) administering to the male patient a series of increasing sublingual doses of apomorphine greater than the threshold dose until a final sublingual apomorphine dose in excess of that needed to produce a penile erection sufficient for penetration has been received by the male patient; and (c) administering to the male patient, prior to sexual activity, a sublingual therapeutic dose of apomorphine less than the final dose but sufficient to produce an erection adequate for penetration without attendant substantial adverse effects. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16)
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17. A method for amelioration of social phobia of a human patient, comprising the steps of:
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(a) administering to the human patient a threshold dose of apomorphine; (b) administering to the human patient a series of increasing periodic doses of apomorphine greater than the threshold dose until a final apomorphine dose in excess of a therapeutic dose of apomorphine has been received by the human patient, the therapeutic dose being an amount sufficient to reduce symptoms of social phobia; and
thereafter(c) administering to the human patient the therapeutic dose of apomorphine. - View Dependent Claims (18)
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19. A method of minimizing adverse effects of apomorphine on a human patient comprising the steps of:
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administering to the human patient a threshold dose of apomorphine; administering to the human patient a series of increasing doses of apomorphine greater than the threshold dose until a final sublingual apomorphine dose in excess of that needed to ameliorate Parkinsonism symptoms has been received by the human patient; and
thereafteradministering to the human patient a therapeutic dose of apomorphine less than the final dose but sufficient to ameliorate Parkinsonism symptoms without attendant substantial adverse effects. - View Dependent Claims (20, 21, 22, 23)
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Specification