Implantable sensor and system for measurement and control of blood constituent levels

• US 5,995,860 A
• Filed: 07/06/1995
• Issued: 11/30/1999
• Est. Priority Date: 07/06/1995
• Status: Expired due to Term

• Current Assignee: Thomas Jefferson University (Main Line Health System)
• Original Assignee: Thomas Jefferson University (Main Line Health System)
• Inventors: Sun, Xiaoguang, Joseph, Jeffrey I.
• Primary Examiner(s): Bahr, Jennifer
• Assistant Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US08/500,388
• Time in Patent Office: 1,608 Days
• Field of Search: 128/633, 128/634, 604/50, 604/66, 604/67, 604/890.1, 604/891.1, 356/39, 600/322, 600/323, 600/310, 600/316, 600/326, 600/327, 600/339, 600/340, 600/341
• US Class Current: 600/341
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/6876 Blood vessel
• CPC Class Codes: A61B 5/6884 Clamps or clips
• CPC Class Codes: A61M 2205/3507 with implanted devices, e.g. external control
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue has at least one source of radiation from infrared through visible light, arranged to direct the radiation at the tissue where it is affected by interaction with the tissue, and a plurality of detectors. Each detector has associated with it a filter transparent to a discrete narrow band of radiation, and each detector provides an output signal representative of detected radiation in that narrow band. The detectors are located with respect to the tissue to receive radiation affected by the tissue. The invention also encompasses a device for measuring and controlling the level of a blood constituent, such as glucose, in a mammal, and includes an implantable infrared source and sensor module for directing infrared radiation through vascular tissue and for sensing the infrared radiation after it has passed through the tissue and generating an output signal representative of the sensed infrared radiation. The device includes a processor module responsive to the output signal from the infrared source and sensor module which performs spectral analysis of the output signal and derives from that analysis a control signal representative of the level of the blood constituent. The device further includes an insulin pump for dispensing doses of insulin in response to the control signal for blood glucose regulation.

Claims

1. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue, comprising:

at least one implantable source of radiation from infrared through visible light, arranged to direct said radiation at said tissue, said radiation being affected directly by interaction with said tissue, and

a plurality of implantable detectors, each having associated with it a filter transparent to a discrete narrow band of radiation, each detector providing an output signal representative of detected radiation in said narrow band, the detectors being located with respect to the tissue to receive said radiation affected directly by interaction with said tissue.

2. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, further comprising a channel having an internal circumference around which are arranged said source and said detectors, said channel being dimensioned to receive a blood vessel therein and to locate said vessel in proximity to said source and detectors.

3. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, further comprising a first half and a second half, one half supporting said at least one source and the other half supporting at least one of said plurality of detectors, said halves being spaced apart and defining a gap therebetween for receiving said vascular tissue therein and locating said tissue in proximity to said source and detectors.

4. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 3, further comprising said halves being separate from one another and movable reciprocally toward and away from each other for varying the size of said gap.

5. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 4, further comprising an adjustable fastener for adjustably fastening said halves together and for adjustably varying the size of said gap.

6. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 5, wherein the adjustable fastener comprises a rotatable screw in one of said halves and a threaded bore receiving said screw in the other of said halves.

7. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein said at least one source and said plurality of detectors are arranged in a linear array, at least one of said plurality of detectors being located opposite said source and spaced therefrom by a distance sufficient to receive said tissue between said source and said detector.

8. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein said at least one source and said plurality of detectors are arranged in a planar array, at least one of said plurality of detectors being located opposite said source and spaced therefrom by a distance sufficient to receive said tissue between said source and said detector.

9. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein at least one detector of said plurality of detectors is located opposite said source and at least one detector of said plurality of detectors is located next to said source.

10. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein at least one of said plurality of detectors is located to detect radiation scattered by said tissue.

11. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein at least one of said plurality of detectors is located to detect radiation transmitted through said tissue.

12. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein at least one of said plurality of detectors is located to detect radiation reflected by said tissue.

13. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein at least one of said plurality of detectors is located to detect radiation scattered by said tissue and at least one of said plurality of detectors is located to detect radiation transmitted through said tissue.

14. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein at least one of said plurality of detectors is located to detect radiation scattered by said tissue, at least one of said plurality of detectors is located to detect radiation transmitted by said tissue, and at least one of said plurality of detectors is arranged to detect radiation reflected by said tissue.

15. An implantable device for sensing in vivo the level of at least one blood constituent in mammalian vascular tissue according to claim 1, wherein at least one optical fiber is used in conjunction with at least a selected one of said source and detectors for conveying said radiation between said selected one of said source and detectors and said tissue.

16. A device for measuring and controlling the level of blood glucose in a mammal, comprising:

an implantable infrared source and sensor module for directing infrared radiation through vascular tissue and for sensing the infrared radiation after it has interacted directly with the tissue and generating an output signal representative of the direct interaction of infrared radiation with the tissue,

a processor module responsive to the output signal from the infrared source and sensor module for performing spectral analysis of the output signal and deriving therefrom a control signal related to the level of said blood glucose, and

an insulin pump for dispensing doses of insulin in response to the control signal.

17. A device for measuring and controlling the level of blood glucose in a mammal according to claim 16, wherein the insulin pump is external to the body of the mammal.

18. A device for measuring and controlling the level of blood glucose in a mammal according to claim 16, wherein the insulin pump is implantable within the body of the mammal.

19. A device for measuring and controlling the level of blood glucose in a mammal according to claim 16, wherein the source and sensor module comprises at least one source of radiation from infrared through visible light, arranged to direct said radiation at said tissue, said radiation being affected by interaction with said tissue, and a plurality of detectors, each having associated with it a filter transparent to a discrete narrow band of radiation, each detector providing an output signal representative of detected radiation in said narrow band, the detectors being located with respect to the tissue to receive radiation from said source affected by said tissue.

20. A device for measuring and controlling the level of a blood constituent in a mammal, comprising

an implantable infrared source and sensor module for directing infrared radiation through vascular tissue and for sensing the infrared radiation after it has interacted directly with the tissue and generating an output signal representative of the direct interaction of infrared radiation with the tissue;

a processor module responsive to the output signal from the infrared source and sensor module for performing spectral analysis of the output signal and deriving therefrom a control signal related to the level of said blood constituent; and

a pump for dispensing doses of medication in response to the control signal.