Method and an automatic system for obtaining water content and electric-permittivity maps from magnetic resonance images

• US 5,995,863 A
• Filed: 12/29/1997
• Issued: 11/30/1999
• Est. Priority Date: 12/27/1996
• Status: Expired due to Fees

• Current Assignee: Fondazione Bruno Kessler
• Original Assignee: Instituto Trentino Di Cultura
• Inventors: Antolini, Renzo, Farace, Paolo, Scarpa, Marina, Pontalti, Rolando, Cristoforetti, Luca
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US08/998,947
• Time in Patent Office: 701 Days
• Field of Search: 600/410, 600/407, 600/430, 324/307, 324/309, 324/310, 324/312
• US Class Current: 600/410
• CPC Class Codes: G01R 33/4804 Spatially selective measurement of temperature or pH
• CPC Class Codes: G01R 33/4828 Resolving the MR signals of different chemical species, e.g. water-fat imaging

Abstract

Magnetic resonance images (NMR, MRI) are subjected to quantitative analysis of the water content of individual regions of the images, preferably with treatment of relaxation effects, correction for non-uniformities, and taking account of the possible presence of fat tissue. Respective electric-permittivity values can be generated from the aforementioned water-content maps to produce electric-permittivity maps of the object observed.

Claims

1. A method of obtaining electric permittivity maps from magnetic resonance images, comprising the steps of:

scanning tissue to obtain magnetic resonance images,

subjecting the magnetic resonance images to quantitative analysis of water content of individual regions of the images so as to create corresponding first maps indicative of respective water-content values, and

associating respective electrical permittivity values with water content values of the first maps and generating second maps corresponding to electric permittivity maps.

2. The method of claim 1, wherein said images contain portions relating to fat tissues, the method further comprising the steps of:

locating the fat tissues within the images so as to identify respective regions of fat tissue in the images, and

determining, for the respective regions of fat tissue, respective values of the water content to be used for association with respective electric permittivity values.

3. The method of claim 2, further comprising locating the fat tissues by segmentation on the basis of a thresholding operation.

4. The method of claim 2, further comprising locating the fat tissues by segmentation on the basis of a thresholding operation followed by the assignment of tabulated electric permittivity values to the segmented region.

5. The method of claim 4, further comprising acquiring two images (M1, M2) corresponding to hyperintense (M1) and hypointense (M2) fat signals, respectively, then subtracting one image (M2) from the other (M1) and then carrying out the thresholding on the difference image.

6. The method of claim 5, further comprising measuring amplitude modulation of a signal induced by chemical shift as a chemical shift phenomenon.

7. The method of claim 6, comprising the step of measuring signal intensity as a function of dephasing time I(TE) expressed in accordance with equation ##EQU3## where I_i is the quadrature signal of the i-th spectral component, Δ

ω

_ij is the frequency difference between the components i and j, and Δ

φ

_ij is the initial phase between the i-th component and the j-th component,

I_i can be expressed as

space="preserve" listing-type="equation">I.sub.i =I.sub.0 exp(-TE/T*.sub.2i) [1.2]

and represents the T*₂ -weighted modulus signal amplitude of the i-th component with the summation extending over all of the spectral components.

8. The method of claim 7, comprising the step of taking into consideration solely the water spectral component and one fat spectral component, performing an estimation on the basis of images acquired at a plurality of echo times (TE), then effecting a multi-parameter fit on the basis of a non-linear curve, and then computing the tissue water-content images.

9. The method of claim 2, further comprising obtaining the respective water content values of the fat-tissue pixels by a chemical shift imaging (CSI) technique.

10. An automatic system for obtaining water-content and electric permittivity maps from magnetic resonance images, comprising:

magnetic-resonance detection means for generating signals corresponding to magnetic resonance images, and

processing means sensitive to the signals corresponding to the magnetic-resonance images and programmed to implement the steps of;

subjecting the magnetic resonance images to quantitative analysis of water content of individual regions of the images so as to create corresponding first maps indicative of respective water-content values, and

associating respective electrical permittivity values with the water content values of the first maps and, generating second maps corresponding to electric permittivity maps.