Method and apparatus for scanning and evaluating matter

• US 5,995,866 A
• Filed: 08/15/1997
• Issued: 11/30/1999
• Est. Priority Date: 03/21/1995
• Status: Expired due to Term

• Current Assignee: Dorothy Lemelson
• Original Assignee: Dorothy Lemelson
• Inventors: Lemelson, Jerome
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US08/911,220
• Time in Patent Office: 837 Days
• Field of Search: 600/310, 600/322, 600/407, 600/473, 600/476, 606/3, 606/10, 606/11, 606/12, 606/13, 250/461.2, 250/578.1, 356/318, 356/303, 128/920
• US Class Current: 600/476
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 2017/00066 intensity
• CPC Class Codes: A61B 2018/00904 Automatic detection of target tissue
• CPC Class Codes: A61B 2018/20351 Scanning mechanisms
• CPC Class Codes: A61B 2018/20361 with redirecting based on sensed condition, e.g. tissue analysis or tissue movement
• CPC Class Codes: A61B 34/10 Computer-aided planning, simulation or modelling of surgical operations
• CPC Class Codes: A61B 34/70 Manipulators specially adapted for use in surgery
• CPC Class Codes: G01N 15/1468 with spatial resolution of the texture or inner structure of the particle

Abstract

A system and method for analyzing matter by computer analysis of electrical signals generated by sensing radiation reflected from matter (i.e. tissue, cells, liquid, gaseous or solid particles in a liquid or gas) and/or generated due to fluorescence. In one embodiment, a short pulse of laser radiation is directed at matter also scanned by an electro-optical scanning means to generate image signals. Fluorescent radiation and reflected radiation generating image signals, generate respective variable electrical signals which are computer processed and analyzed to detect and determine the chemical and/or biological composition of the matter. A television camera scans the matter and generates video signals for computer processing and analysis. Simultaneously or sequentially, pulsed laser energy is directed against plural locations of scanned matter, wherein each of such pulses generates a short duration of fluorescent energy in different select portions of the matter under analysis. Fluorescing light is photoelectrically detected generating variable electrical signals for each portion of fluorescing matter, which signals are computer processed and analyzed along with signals output by the television camera to provide information used to intelligibly indicate: (a) composition of such matter, (b) presence of one or more chemical and/or biological agents in such matter, (c) whether the matter is defective or diseased or, (d) a combination of such indications. The liquid may be any body fluids Manipulators are provided to move the TV camera, lasers, sensors and treatment lasers and/or surgical instruments.

Claims

1. A method of electro-optically scanning matter within a given region comprising the steps of:

(a) generating a first beam of radiation;

(b) directing said first beam of radiation into said matter;

(c) generating a second beam of radiation;

(d) directing said second beam of radiation into said matter so that the second beam of radiation intersects with the first beam of radiation at a location within said matter to excite said matter at said location, said first and second beams of radiation intersecting at a given angle;

(e) photoelectrically detecting the excited location and generating first variable electrical signals;

(f) digitizing said first variable electrical signals and generating first digital code signals;

(g) spectrally analyzing said first digital code signals with a computer and generating second code signals; and

(h) employing said second code signals to intelligibly indicate a presence of a constituent in said matter at said location.

2. The method of claim 1 wherein said angle is an acute angle.

3. The method of claim 1 wherein said angle is a right angle.

4. The method of claim 1 wherein step (f) further comprises determining if said constituent is a type of molecule.

5. The method of claim 1 wherein step (f) further comprises determining if said constituent is a given material.

6. The method of claim 1 wherein step (f) further comprises determining if said constituent is a given element.

7. The method of claim 1 wherein step (f) further comprises determining if said constituent is a diseased element.

8. The method of claim 1 wherein step (f) further comprises determining if said constituent is a cancerous element.

9. The method of claim 1 further comprising moving said first and second beams so that said first and second beams cooperatively scan at least a given portion of said fluid.

10. The method of claim 9 further comprising the step of generating time code signals during scanning and employing said time code signals to indicate a location in the scan.

11. The method of claim 1 wherein said matter is a fluid and said beams are caused to intersect at a region within said fluid.

12. The method of claim 11 wherein said fluid is blood and said beams are caused to intersect at a region within said fluid.

13. The method of claim 11 wherein said fluid is a gas and said beams are caused to intersect at a region within said fluid.

14. The method of claim 11 wherein said fluid is a liquid and said beams are caused to intersect at a region within said fluid.

15. A method of electro-optically scanning matter within a given region, comprising the steps of:

(a) generating a first beam of radiation;

(b) directing said first beam of radiation into said matter;

(c) generating a second beam of radiation;

(d) directing said second beam of radiation into said matter so that said second beam of radiation intersects with the first beam of radiation at a location within said matter to excite matter at said location;

(e) controlling the intensity of said beams so that a sum of radiation of said beams is sufficient to excite said matter at said location while the radiation of the individual beams is insufficient to excite the matter at said location.

16. The method of claim 15 wherein said sum of said radiation of said beams is sufficient to cause the matter at said location to fluoresce.

17. The method claim 15 wherein said first and second beams are each scanned in at least two mutually perpendicular directions.

18. The method of claim 15 wherein said first and second beams are each scanned in at least three mutually perpendicular directions.

19. The method of claim 15 wherein said sum of said radiation is chosen to destroy matter at said location.

20. The method of claim 19 wherein said matter includes one of bacteria, virus and cancer cells.

21. The method of claim 15 further comprising:

(a) photoelectrically detecting the excited location and generating first variable electrical signals;

(b) digitizing said first variable electrical signals and generating first digital code signals;

(c) spectrally analyzing said first digital code signals with a computer and generating second code signals; and

(d) employing said second code signals to intelligibly indicate a presence of certain matter at said location.

22. A method of treating matter, comprising the steps of:

(a) generating a first beam of radiation;

(b) directing said first beam of radiation into said matter;

(c) generating a second beam of radiation;

(d) directing said second beam of radiation into said matter so that the second beam of radiation intersects with the first beam of radiation at a location within said fluid to excite said matter at said location; and

(e) controlling the intensity of the first and second beams of radiation so that their sum is sufficient to record digital data in said material.

23. A method of treating matter, comprising the steps of:

(a) generating a first beam of radiation;

(b) directing said first beam of radiation into said matter;

(c) generating a second beam of radiation;

(d) directing said second beam of radiation into said matter so that the second beam of radiation intersects with the first beam of radiation at a given angle and at a location within said matter to excite said matter at said location; and

(e) controlling radiation intensity of said first and second beams of radiation to chemically change matter at the location intersected by said first and second beams of radiation.

24. The method of claim 23 wherein said matter is a radiation curable photo-polymer and said photo-polymer is cured at said location by a sum of said first and second beams of radiation.