Breath test for detection of lung cancer

• US 5,996,586 A
• Filed: 10/16/1997
• Issued: 12/07/1999
• Est. Priority Date: 03/26/1997
• Status: Expired due to Term

• Current Assignee: Michael Phillips
• Original Assignee: Michael Phillips
• Inventors: Phillips, Michael
• Primary Examiner(s): Yu, Mickey
• Assistant Examiner(s): O'Hara, Kelly
• Application Number:
  US08/951,884
• Time in Patent Office: 782 Days
• Field of Search: 128/898, 128/206.29, 128/204.17, 600/532, 600/543, 600/473, 436/64, 436/900, 436/96, 436/813
• US Class Current: 128/898
• CPC Class Codes: A61B 10/00 Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis vaccination prophylaxis, vaccination therapy A61B17/20; Sex determination; Ovulation-period determination menstruation tables G06C3/00; Throat striking implements
• CPC Class Codes: A61B 2010/0087 Breath samples
• CPC Class Codes: A61B 5/082 Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath A61B5/083, A61B5/091 take precedence
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: G01N 2033/4975 other than oxygen, carbon dioxide or alcohol, e.g. organic vapours
• CPC Class Codes: Y10S 977/904 for medical, immunological, body treatment, or diagnosis

Abstract

A method of detecting and diagnosing the probable presence of lung cancer in a mammal, including a human, comprising collecting a measured quantity of alveolar breath from the mammal; analyzing the collected breath for the presence of a marker for lung cancer; determining a first mean alveolar gradient for the marker present in the mammal'"'"'s breath; comparing the first mean alveolar gradient for the marker present in the mammal'"'"'s breath to a second mean alveolar gradient for the same marker, found in the breath of a mammal free of lung cancer.

Claims

1. A method of detecting and diagnosing the probable presence of lung cancer in a mammal, including a human, which comprises;

collecting a measured quantity of alveolar breath from the mammal;

analyzing the collected breath for the presence of a marker for lung cancer;

said marker being a chemical compound selected from the group consisting of

2-heptanone,

4-methyl-nonane,

heptanal,

2-methyl-nonane,

1,1'"'"'-bicyclopentyl,

nonane,

4-methyl-octane,

hexanal,

propyl-cyclohexane,

trideuteroacetonitrile,

5-methyl-2-hexanamine,

1-butyl-2methyl, cis-cyclopropane,

1,1,3-trimethyl-cyclohexane,

2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-ethane,

3-ethyl-2-methy-heptane,

1,3-dimethyl-, trans-cyclohexane,

3-(methylthio)-1-propene,

3,6-dimethyl-octane,

2,3-dimethyl-pentane,

chloroform,

1-(1-methyl-2-cyclopenten-1-yl)-ethanone,

2-cyano-acetamide,

4-(1,1-dimethylethyl)-cyclohexene,

1-methyl-4-(1-methylethenyl)-, (R)-cyclohexene,

1,1-dimethyl-cyclopropane,

2-methoxy-ethyl, acetate,

1-methyl-1-(1-methylethyl)hydrazine,

trans-anti-1-methyl-decahydronaphthalene,

ethynyl-benzene,

2-methylbutylidene-cyclopentane,

octahydro 4,7-ethano-1H-indene,

5-methoxy-1-aza-6-oxabicyclo(3.1.0)hexane,

1,1-dimethylcyclohexane,

4-(1-methylethyl)-heptane,

1,4-dimethyl-, -ciscyclohexane,

pentanal,

3-methyl-nonane,

1,2,3-trimethyl-, (1α

,2β

,3α

)cyclohexane,

2-beta-pinene,

-Triethylborane,

2,5-dimethyl-, cis-piperazine,

delta-4-carene,

2-methyl-, 2-methylbutyl propanoic acid ester and

3-methyl-pentane;

determining a first mean alveolar gradient for the marker present in the mammal'"'"'s breath;

comparing the first mean alveolar gradient for the marker present in the mammal'"'"'s breath to a second mean alveolar gradient for the same marker, found in the breath of a mammal free of lung cancer;

wherein a statistically significant difference in the first mean alveolar gradient from the second mean alveolar gradient indicates the probable presence of lung cancer.