Skin care compositions and method of improving skin appearance

• US 5,997,890 A
• Filed: 04/06/1998
• Issued: 12/07/1999
• Est. Priority Date: 05/23/1997
• Status: Expired due to Term

• Current Assignee: The Procter & Gamble Company
• Original Assignee: The Procter & Gamble Company
• Inventors: Sine, Mark Richard, Dawes, Nancy Coultrip, SaNogueira, James Pedrosa Jr.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): HOWARD, SHARON LEE
• Application Number:
  US09/056,028
• Time in Patent Office: 610 Days
• Field of Search: 424/401, 514/938, 514/937, 514/947
• US Class Current: 424/401
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 8/29 Titanium; Compounds thereof
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61K 8/675 Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde tocopheryl nicotinate A61K8/678
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

Disclosed are topical compositions which are useful for providing essentially immediate improvements in skin appearance, e.g., good coverage of skin imperfections, e.g., pores and uneven skin tone, in addition to chronic improvements in skin appearance, while retaining a natural skin appearance. The compositions contain a particulate material having a refractive index of at least about 2, e.g., TiO₂, and an active for regulating skin condition following multiple topical applications of the composition. Preferred actives include Vitamin B₃ compounds and retinoids.

Claims

1. A topical composition comprising:

(a) from about 0.3% to about 2% of pigmentary grade particulate material selected from the group consisting of TiO₂, ZrO₂ and combinations thereof, said particulate material having a refractive index of at least about 2, the particulate material being dispersed in the composition and having a neat primary particle size of greater than 100 nm to about 300 nm;

(b) a safe and effective amount of an active effective for chronically regulating skin condition selected from the group consisting of Vitamin B3 compounds, retinoids, and mixtures thereof; and

(c) a topical carrier.

2. The composition of claim 1 wherein the composition comprises from about 0.5% to about 1% of the particulate material.

3. The composition of claim 1 wherein the particulate material has a refractive index of from about 2 to about 3.

4. The composition of claim 1 wherein the particulate material consists essentially of TiO₂.

5. The composition of claim 1 wherein the active is selected from the group consisting of niacinamide, retinol, retinol esters, and mixtures thereof.

6. The composition of claim 1 wherein the active is niacinamide.

7. The composition of claim 1 wherein the active is selected from retinol, retinol esters, and mixtures thereof.

8. The composition of claim 1 wherein the particulate material has a neat primary particle size of from about 150 nm to about 300 nm.

9. The composition of claim 1 wherein the particulate material has a neat primary particle size of from about 200 nm to about 250 nm.

10. The composition of claim 1 wherein the particulate material has a primary particle size when dispersed in the composition of greater than 100 nm to about 1000 nm.

11. The composition of claim 1 wherein the composition has an apparent viscosity of from about 5,000 to about 200,000 centipoise.

12. The composition of claim 1 wherein the composition comprises a continuous hydrophilic phase and a hydrophobic phase dispersed in the hydrophilic phase.

13. The composition of claim 1 wherein the composition is an oil-in-water emulsion.

14. The composition of claim 13 wherein the composition comprises one or more compounds selected from the group consisting of emulsifiers, surfactants, structuring agents, thickening agents and combinations thereof.

15. The composition of claim 1 comprising a skin conditioning component.

16. The composition of claim 1 wherein the composition is a leave-on composition.

18. A method of regulating skin condition comprising topically applying the composition of claim 1.

19. The method of claim 18, wherein regulating skin condition comprises masking or covering textural discontinuities in skin and/or providing a more even skin tone or color, without whitening the skin.

17. A topical oil-in-water emulsion composition comprising:

(a) from about 0.3% to about 2% of pigmentary grade particulate material selected from the group consisting of TiO₂, ZrO₂, and combinations thereof, the particulate material being dispersed in the composition and having a neat primary particle size of from about 150 nm to about 300 nm;

(b) niacinamide in an amount safe and effective for chronically regulating skin condition; and

(c) a topical carrier.