Dural/meningeal repair product using collagen matrix
DCFirst Claim
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1. A method for promoting meningeal tissue growth to replace a damaged meningeal tissue, said method comprising;
- providing certified collagen prepared by a process certified to provide physiologically compatible collagen which is free of effective amounts of active viruses and prions;
forming a cross-linked matrix comprising said certified collagen and pores having a diameter of 10-500 micrometers that permit growing meningeal tissue to infiltrate said matrix, wherein said matrix is substantially free of non-collagenous proteins;
contacting said matrix and said damaged meningeal tissue;
maintaining said contact between said matrix and said damaged meningeal tissue to promote meningeal tissue growth through said matrix; and
substantially resorbing said matrix.
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Abstract
Dural substitutes are provided, which include collagen treated and/or prepared to be physiologically compatible and substantially free of active viruses and prions. Suitable forms for the dural substitutes include a sponge, a film, a non-woven matrix, a felt or a combination of at least two of the foregoing forms. Also provided are a method for preparing dural substitutes and a method for promoting meningeal tissue growth.
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Citations
78 Claims
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1. A method for promoting meningeal tissue growth to replace a damaged meningeal tissue, said method comprising;
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providing certified collagen prepared by a process certified to provide physiologically compatible collagen which is free of effective amounts of active viruses and prions; forming a cross-linked matrix comprising said certified collagen and pores having a diameter of 10-500 micrometers that permit growing meningeal tissue to infiltrate said matrix, wherein said matrix is substantially free of non-collagenous proteins; contacting said matrix and said damaged meningeal tissue; maintaining said contact between said matrix and said damaged meningeal tissue to promote meningeal tissue growth through said matrix; and substantially resorbing said matrix. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66)
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67. A method for promoting meningeal tissue growth to replace a damaged meningeal tissue, said method comprising:
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providing certified collagen prepared by a process certified to provide physiologically compatible collagen which is free of effective amounts of active viruses and prions; forming a cross-linked matrix consisting essentially of said certified collagen and optionally, at least one meningeal tissue growth factor, wherein said matrix has pores having a diameter of 10-500 micrometers that permit growing meningeal tissue to infiltrate said matrix; contacting said matrix and said damaged meningeal tissue; maintaining said contact between said matrix and said damaged meningeal tissue to promote meningeal tissue growth through said matrix; and substantially resorbing said matrix. - View Dependent Claims (68)
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69. A matrix for promoting meningeal tissue growth to replace a damaged meningeal tissue, said matrix prepared by a process comprising:
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providing certified collagen fibers which are physiologically compatible and certified to be free of effective amounts of active viruses and prions; dispersing said certified collagen fibers in a liquid medium to provide a collagen dispersion; and evaporating said liquid medium from said collagen dispersion to provide said matrix; wherein said matrix comprises said certified collagen fibers and pores having a diameter of 50-150 micrometers adapted to permit growing meningeal tissue to infiltrate said pores, said matrix is substantially free of non-collagenous proteins, and said matrix is adapted to be resorbed within about three months after implantation. - View Dependent Claims (70, 71, 72, 73, 74, 75, 76, 77)
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78. A matrix for promoting meningeal tissue growth to replace a damaged meningeal tissue, said matrix prepared by a process comprising:
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providing certified collagen fibers which are physiologically compatible and certified to be free of effective amounts of active viruses and prions; providing at least two different volumes of a liquid medium containing said certified collagen; and evaporating said liquid medium from each of said different volumes to provide at least two different members of the group consisting of a film, a sponge, a non-woven and a felt, and wherein said matrix comprises said at least two different members, said certified collagen fibers, and pores having a diameter of 50-150 μ
m adapted to permit growing meningeal tissue to infiltrate said pores, and wherein said matrix is substantially free of non-collagenous proteins, and said matrix is adapted to be resorbed within about three months after implantation.
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Specification