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Systematic evolution of ligands by exponential enrichment: chemi-SELEX

  • US 5,998,142 A
  • Filed: 08/21/1997
  • Issued: 12/07/1999
  • Est. Priority Date: 09/08/1993
  • Status: Expired due to Fees
First Claim
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1. Nucleic acid ligands that bind covalently with a protein, wherein said nucleic acid ligands comprise a chemically reactive functional unit, wherein said nucleic acid ligands are produced by the method comprising the steps of:

  • a) preparing a candidate mixture of nucleic acids;

    b) contacting the candidate mixture with said protein, wherein nucleic acids which bind covalently with said protein may be partitioned from the remainder of the candidate mixture;

    c) partitioning the nucleic acids that bind covalently with the protein from the remainder of the candidate mixture; and

    d) amplifying the nucleic acids that bind covalently with the protein, whereby nucleic acid ligands that bind covalently with the protein may be produced.

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