BH3 interacting domain death agonist
First Claim
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1. An isolated and purified BID (BH3 Interacting domain Death agonist) polypeptide comprising an amino acid sequence which is at least 85 percent identical to the amino acid sequence set forth in SEQ ID NO:
- 4.
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Abstract
A novel death agonist, BID, which contains only a BH3 domain but not the BH1, BH2, BH4 or membrane anchoring domains found in related BCL-2 family members is provided along with derivatives of BID, bid polynucleotides and derivatives thereof and compositions and uses therefor.
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Citations
15 Claims
- 1. An isolated and purified BID (BH3 Interacting domain Death agonist) polypeptide comprising an amino acid sequence which is at least 85 percent identical to the amino acid sequence set forth in SEQ ID NO:
- 3. An isolated and purified BID polypeptide which (a) lacks the carboxyl terminal signal-anchor sequence characteristic of the membrane bound members of the BCL-2 family, (b) lacks BH1 and BH2 domains, (c) has a BH3 domain, and (d) heterodimerizes with BAX, BCL-2 or BCL-XL.
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9. An isolated and purified polypeptide comprising an immunogenic fragment of at least 10 contiguous amino acids of a BID polypeptide as set forth in SEQ ID NO:
- 4
(MDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGMD), SEQ ID NO;
5(MDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNVRTLEGMD), or SEQ ID NO;
6(MDSEVSNGSGLGAKHITDLLVFGFLQSSGCTRQELEVLGRELPVQAYWEADLEDELQTDGSQASRSFNQGRIEPDSESQEEIIHNIARHLAQIGDEMDHNIQPTLVRQLAAQFMNGSLSEEDKRNCLAKALDEVKTAFPRDMENDKAMLIMTMLLAKKVASHAPSLLRDVFHTTVNFINQNLFSYVRNLVRNEMD). - View Dependent Claims (10)
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11. The isolated and purified fragment of claim 11 which has the sequence as set forth in SEQ ID NO:
- 51, SEQ ID NO;
52 or SEQ ID NO;
53.
- 51, SEQ ID NO;
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14. The isolated and purified fusion protein according to claim 14 wherein the heterologous polypeptide sequence is a Tat peptide as set forth in SEQ ID NO:
- 54 (YGRKKRRQRRR).
- View Dependent Claims (13)
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15. The isolated and purified fusion protein of claim 16 comprising the sequence as set forth in SEQ ID NO:
- 56 (YGRKKRRQRRRGDSESQEEIIHNIARHLAQIGDEMDHNIQPTLV).
Specification