Haloisoquinoline carboxamide
First Claim
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1. A compound of the formula:
- ##STR4## Wherein X, Y and Z, independently of one another, are selected from the group consisting of H, F, 18 F, I, 123 I, 124 I, 125 I, 131 I, Br, 75 Br, 76 Br, 77 Br, 82 Br, 210 At, 211 (R1)W or (R2)V;
R is --(R1)W, wherein W is selected from the group consisting of F, and 18 F, and wherein R1 is a linear or branched alkyl comprising from 1 to about 4 carbon atoms, R2 is vinyl, wherein V is I, 123 I, 124 I, 125 I or 131 I; and
at least one of X, Y or Z is not H.
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Abstract
Compounds of the invention have the general structure ##STR1## X, Y or Z are, respectively independently, H, F or an isotope thereof, Br or an isotope thereof, I or an isotope thereof, At or an isotope thereof, (R1)W or (R2)V and R is --(R1)W, when W is H or F or an isotope thereof, R1 is linear or branched alkyl of 1-4 carbon atoms, R2 is vinyl, V is I or an isotope thereof and at least one of X, Y or Z is not H. The compounds of the invention bind to PK receptors.
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Citations
18 Claims
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1. A compound of the formula:
- ##STR4## Wherein X, Y and Z, independently of one another, are selected from the group consisting of H, F, 18 F, I, 123 I, 124 I, 125 I, 131 I, Br, 75 Br, 76 Br, 77 Br, 82 Br, 210 At, 211 (R1)W or (R2)V;
R is --(R1)W, wherein W is selected from the group consisting of F, and 18 F, and wherein R1 is a linear or branched alkyl comprising from 1 to about 4 carbon atoms, R2 is vinyl, wherein V is I, 123 I, 124 I, 125 I or 131 I; and
at least one of X, Y or Z is not H. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
- ##STR4## Wherein X, Y and Z, independently of one another, are selected from the group consisting of H, F, 18 F, I, 123 I, 124 I, 125 I, 131 I, Br, 75 Br, 76 Br, 77 Br, 82 Br, 210 At, 211 (R1)W or (R2)V;
Specification